AI Article Synopsis
- Anthrax poses a significant public health threat, with rare cases linked to strains that aren't typically associated with the disease.
- Whole-genome sequencing was used to analyze three isolates from two anthrax cases involving welders in 2020 in the U.S., revealing they belonged to different species based on genetic comparison.
- One isolate from Louisiana had genes for certain virulence factors, while an isolate from Texas did not, shedding light on the genetic diversity and evolution of anthrax-causing bacteria.
Article Abstract
Anthrax-causing members of () pose a serious threat to public health. While most anthrax-causing strains resemble phenotypically, rare cases of anthrax-like illness caused by strains resembling "" have been reported. Here, whole-genome sequencing was used to characterize three isolates associated with two 2020 welder anthrax cases in the United States, which resembled "" phenotypically. Comparison of the three genomes sequenced here to all publicly available, high-quality genomes ( = 2890 total genomes) demonstrated that genomes associated with each case effectively belonged to separate species at the conventional 95% average nucleotide identity prokaryotic species threshold. Two PubMLST sequence type 78 (ST78) genomes affiliated with a case in Louisiana were most closely related to and possessed genes encoding the Bps exopolysaccharide capsule, as well as hemolysin BL (Hbl) and cytotoxin K (CytK). Comparatively, a ST108 genome associated with a case in Texas was most closely related to ; however, like other anthrax-causing strains most closely related to , this genome did not possess Bps-, Hbl-, or CytK-encoding genes. Overall, results presented here provide insights into the evolution of anthrax-causing
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413466 | PMC |
| http://dx.doi.org/10.3390/pathogens11080856 | DOI Listing |
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