Energy Balance & Body Composition Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX 79409, USA.
Published: August 2022
AI Article Synopsis
Article Abstract
Multivitamin/mineral (MVM) supplements are one of the most popular dietary supplement categories. The purpose of this analysis was to determine if a novel liposomal delivery mechanism improves mineral absorption from an MVM product. In a randomized crossover trial, 25 healthy participants (12 females, 13 males) completed two testing sessions in which blood samples were collected at baseline and 2, 4, and 6 h following the ingestion of either a liposomal MVM or a nutrient-matched standard MVM. Analysis of MVM products indicated an elemental iron content of 9.4 and 10.1 mg (~50% U.S. FDA Daily Value) and an elemental magnesium content of 22.0 and 23.3 mg (~5% U.S. FDA Daily Value) in the liposomal and standard MVM products, respectively. Blood samples were analyzed for concentrations of iron and magnesium using colorimetric assays. Changes in mineral concentrations were analyzed using linear mixed models, and pharmacokinetic parameters were compared between conditions. For iron, statistically significant condition × time interactions were observed for percent change from baseline ( = 0.002), rank of percent change from baseline ( = 0.01), and raw concentrations ( = 0.02). Follow-up testing indicated that the liposomal condition exhibited larger changes from baseline than the standard MVM condition at 4 ( = 0.0001; +14.3 ± 18.5% vs. -6.0 ± 13.1%) and 6 h ( = 0.0002; +1.0 ± 20.9% vs. -21.0 ± 15.3%) following MVM ingestion. These changes were further supported by a 50% greater mean incremental area under the curve in the liposomal condition (33.2 ± 30.9 vs. 19.8 ± 19.8 mcg/dL × 6 h; = 0.02, Cohen's effect size = 0.52). In contrast, no differential effects for magnesium absorption were observed. In conclusion, iron absorption from an MVM product is enhanced by a liposomal delivery mechanism.
Chronic low back pain is a prevalent and debilitating condition that often resists traditional management strategies such as physical therapy, pharmacotherapy, and interventional procedures. The erector spinae plane (ESP) block, a relatively new regional anesthesia technique, has shown promise in managing various types of pain, including chronic conditions. This case report details the use of the ESP block in a male patient in his late 60's with chronic low back pain unresponsive to conventional treatments, including acetaminophen, muscle relaxants, gabapentin, epidural steroid injections, diagnostic medial branch blocks, and sacroiliac joint injections.
Supraventricular tachycardia (SVT) is one of the most common cardiac arrhythmias, characterized by a sudden increase in heart rate. Initial management often involves vagal maneuvers, including the Valsalva maneuver (VM) and carotid sinus massage (CSM). VM can be categorized into standard VM (sVM) and modified VM (mVM).
- A systematic review and meta-analysis investigated the effectiveness and safety of quadruplet regimens (anti-CD38 mAbs, proteosome inhibitors, and immunomodulatory drugs) for newly diagnosed multiple myeloma (NDMM), finding seven randomized controlled trials with 3,716 participants.
- Results showed that quadruplets significantly improved overall response rate (ORR), progression-free survival (PFS), and minimal residual disease (MRD) negativity compared to triplet regimens, offering better overall survival (OS) as well.
- Although quadruplets did lead to a slight increase in serious infections, they are suggested as a new standard of care, especially for transplant-eligible patients with NDMM, due to their overall enhanced
Preservation of cultural heritage sites is of paramount importance. The ruins of Carmo Convent in Lisbon stand as a poignant reminder of the city's rich history, but challenges regarding structural integrity and safety are present in a highly populated and touristic area. In this paper, a comprehensive study of the Carmo Convent is presented, focused on non-destructive testing (NDT), structural health monitoring (SHM) and numerical modelling.
Treatment of relapsed/refractory multiple myeloma (RRMM) is challenging as patients exhaust all available therapies and the disease becomes refractory to standard drug classes. Here we report the final results of LocoMMotion, the first prospective study of real-world clinical practice (RWCP) in triple-class exposed (TCE) patients with RRMM, with a median follow-up of 26.4 months (range, 0.
