AI Article Synopsis
- - Sarcopenia is defined as the loss of skeletal muscle mass, strength, and physical performance, and the role of alcohol consumption as a risk factor for it has been unclear, with previous studies showing inconsistent results.
- - A systematic review and meta-analysis of 19 observational studies involving 3826 sarcopenia patients showed no significant association between alcohol consumption and the risk of sarcopenia overall, though some subgroup analyses suggested alcohol might slightly decrease the risk in men.
- - The analysis found that younger adults (<65 years) had a higher risk of sarcopenia associated with alcohol consumption, indicating that factors like age, smoking, and dietary patterns may influence this relationship, highlighting the need for further research on
Article Abstract
Sarcopenia is a common disease defined as the loss of skeletal muscle mass, strength, and physical performance. Alcohol consumption is an uncertain risk factor for sarcopenia. Previous observational epidemiological studies have reported inconsistent results regarding the association between alcohol consumption and sarcopenia risk. This study aimed to investigate the association between alcohol consumption and sarcopenia. A literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched PubMed, EMBASE, and the Cochrane Library through April 2022 using keywords related to alcohol consumption and sarcopenia. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using a random effects model meta-analysis. The risk of bias of the studies was assessed using the Newcastle−Ottawa scale. Nineteen observational studies that reported 3826 sarcopenia patients among 422,870 participants were included in the qualitative analysis. Alcohol consumption was not significantly associated with sarcopenia risk (OR, 1.00; 95% CI, 0.83 to 1.20; I2 = 60.6%). Alcohol consumption resulted in a non-significant decrease in the risk of sarcopenia in men (OR, 0.70; 95% CI, 0.46 to 1.07; I2 = 0.0%) and in women (OR, 1.20; 95% CI, 0.63 to 2.30; I2 = 75.8%). The subgroup analyses by age and alcohol consumption were significantly associated with an increased the risk of sarcopenia in <65 years (OR, 2.62; 95% CI, 1.22 to 5.62; I2 = 100%). This meta-analysis of observational studies indicated that alcohol consumption was not significantly associated with sarcopenia risk. However, there are factors influencing the association between alcohol consumption and sarcopenia, such as smoking and dietary patterns. Additional study of these confounding factors is needed for the systematic analysis of the association of alcohol consumption with sarcopenia in future studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415919 | PMC |
| http://dx.doi.org/10.3390/nu14163266 | DOI Listing |
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