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Background: This study investigates the effects of intranasal dantrolene nanoparticles on inflammation and programmed cell death by pyroptosis in 5XFAD Alzheimer's Disease (AD) mice.
Methods: 5XFAD and wild type (WT) B6SJLF1/J mice were treated with intranasal dantrolene nanoparticles (5 mg/kg), daily, Monday to Friday, for 12 weeks continuously, starting at 9 months of age. Blood and brain were harvested at 13 months of age, one month after completion of 12 weeks intranasal dantrolene nanoparticle treatment.
Cross-domain binding of anti-fibrillation peptide TNGQ to islet amyloid polypeptide provides cytoprotective effects in giant unilamellar vesicles and pancreatic β-cells.
Food Funct
December 2024
School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, K1H 8M5, Canada.
Islet amyloid polypeptide (IAPP) fibrillation induces β-cell dysfunction and toxicity in patients with type 2 diabetes. Cytotoxicity is caused by the ability of IAPP fibrils and fibrillar intermediates to permeate the cellular membrane of pancreatic β-cells, trigger endoplasmic reticular stress, induce reactive oxygen species production, and upregulate apoptosis-related genes. Thus, inhibition of IAPP fibrillation is of great interest for preventing associated cytotoxicity.
View Article and Find Full Text PDFInfluence of anti-fibrillation TNGQ peptide and rutin combination on β-cell cytoprotective effects against IAPP-induced cell death and oxidative stress.
Biochem Biophys Res Commun
December 2024
School of Nutrition Sciences, Health Sciences, University of Ottawa, Ottawa, K1H 8M5, Canada; Department of Chemistry and Biomolecular Sciences, Science, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada; University Food Properties and Nutrient Bioavailability, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada. Electronic address:
Article Synopsis
- Type 2 diabetes is linked to IAPP fibrillation, which damages pancreatic β-cells through oxidative stress and membrane disruption.
- Rutin, a plant polyphenol, and certain bioactive peptides (TNGQ, MANT, YMSV) show promise as inhibitors for IAPP fibrillation.
- The study found that combining rutin with TNGQ significantly reduced IAPP fibrillation and related cell toxicity, suggesting potential for creating new anti-diabetic nutraceuticals.
Ultrasmall Black Phosphorus Quantum Dots with Robust Antioxidative Properties for Acute Kidney and Liver Injury Therapy.
Small
January 2025
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou, Guangdong, 511400, China.
Acute organ injuries, such as acute kidney injury (AKI) and acute liver injury (ALI), usually present high morbidity and mortality in patients. However, the current clinical treatments remain limited, especially the lack of effective drug-based treatment. Since these acute injuries are often associated with reactive oxygen species (ROS) overproduction, it is a promising strategy to develop therapeutic agents with potent ROS scavenging ability and excellent biocompatibility for efficient antioxidation therapy.
View Article and Find Full Text PDFSilybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis.
Phytother Res
December 2024
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Article Synopsis
- - Liver disease is a major global health issue, and silybin, derived from Silybum marianum, shows promise in treating various liver conditions due to its anti-inflammatory, antioxidative, and protective properties.
- - Despite its potential, silybin faces challenges like low solubility and bioavailability, prompting researchers to create advanced formulations using approaches like targeting specific liver receptors and employing nanotechnology.
- - The study reviews recent research on these silybin formulations, highlighting their application in liver disease treatment and noting the need for more thorough studies to assess their effectiveness and safety.
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