Treatment of infection in people living with HIV is associated with several challenges, including those related to drug metabolism which plays a major role in treatment efficacy. In this review, we will discuss the enzymes involved in the metabolism of anti- and anti-HIV drugs to provide a basis for understanding the potential for interactions between these drug classes. We will also provide a clinical perspective on other issues related to the treatment of and HIV infections such as comorbidities, adherence, and peer communication. Finally, based on our understanding of the interplay between the above issues, we propose a new concept "Antimicrobial susceptibility testing-drug interaction-supports-referent physician" (AISR), to provide a framework for improving rates of eradication in people living with HIV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413132 | PMC |
| http://dx.doi.org/10.3390/microorganisms10081541 | DOI Listing |
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