AI Article Synopsis

  • Researchers are exploring new drugs for depression by focusing on interleukin 6 receptors instead of traditional antidepressants that mainly target monoamine neurotransmitters.
  • A study utilized genomic analysis, specifically looking at single nucleotide polymorphism (SNP) data, to identify genes linked to depression and match them with potential drug candidates.
  • The findings highlight seven genes significantly associated with depression and suggest 20 drugs in development, with sarilumab and satralizumab showing particular promise for repurposing in depression treatment.

Article Abstract

From inadequate prior antidepressants that targeted monoamine neurotransmitter systems emerged the discovery of alternative drugs for depression. For instance, drugs targeted interleukin 6 receptor ( in inflammatory system. Genomic analysis-based drug repurposing using single nucleotide polymorphism (SNP) inclined a promising method for several diseases. However, none of the diseases was depression. Thus, we aimed to identify drug repurposing candidates for depression treatment by adopting a genomic-analysis-based approach. The 5885 SNPs obtained from the machine learning approach were annotated using HaploReg v4.1. Five sets of functional annotations were applied to determine the depression risk genes. The STRING database was used to expand the target genes and identify drug candidates from the DrugBank database. We validated the findings using the ClinicalTrial.gov and PubMed databases. Seven genes were observed to be strongly associated with depression (functional annotation score = 4). Interestingly, was auspicious as a target gene according to the validation outcome. We identified 20 drugs that were undergoing preclinical studies or clinical trials for depression. In addition, we identified sarilumab and satralizumab as drugs that exhibit strong potential for use in the treatment of depression. Our findings indicate that a genomic-analysis-based approach can facilitate the discovery of drugs that can be repurposed for treating depression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405592PMC
http://dx.doi.org/10.3390/biomedicines10081947DOI Listing

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