AI Article Synopsis
- * Clinical trials support curcumin's effectiveness against multiple cancer types, despite challenges such as poor water solubility and low bioavailability, which can be addressed using nanotechnology.
- * While curcumin can cause mild side effects like diarrhea and nausea, it is generally considered safe and tolerable, making it a promising option for cancer prevention and management.
Article Abstract
Cancer is the leading cause of death in the world. Curcumin is the main ingredient in turmeric ( L.), and is widely used in the food industry. It shows anticancer properties on different types of cancers, and the underlying mechanisms of action include inhibiting cell proliferation, suppressing invasion and migration, promoting cell apoptosis, inducing autophagy, decreasing cancer stemness, increasing reactive oxygen species production, reducing inflammation, triggering ferroptosis, regulating gut microbiota, and adjuvant therapy. In addition, the anticancer action of curcumin is demonstrated in clinical trials. Moreover, the poor water solubility and low bioavailability of curcumin can be improved by a variety of nanotechnologies, which will promote its clinical effects. Furthermore, although curcumin shows some adverse effects, such as diarrhea and nausea, it is generally safe and tolerable. This paper is an updated review of the prevention and management of cancers by curcumin with a special attention to its mechanisms of action.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405286 | PMC |
| http://dx.doi.org/10.3390/antiox11081481 | DOI Listing |
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