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| http://dx.doi.org/10.1186/s40462-022-00334-5 | DOI Listing |
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Green Cities, Healthier Children: The Effect of Expanding Urban Green Space on Body Weight for Primary School Starters.
Health Econ
December 2024
Faculty of Business, Economics and Social Sciences, University of Hamburg, Hamburg, Germany.
The discussion on tackling childhood obesity is often centered around fostering physical activity. A potential relationship yet overlooked could run from providing the proper environment for healthy lifestyles to reduced weight problems. A unique quasi-experimental setting of transforming former airport grounds to a large urban green space allows me to apply a difference-in-differences approach within an intention-to-treat framework, comparing several weight outcomes of residential children to children living further away before and after park opening.
View Article and Find Full Text PDFPATHOMORPHOLOGICAL AND CLINICAL CHARACTERISTICS OF THE UTERUS IN COMBINED ADENOMYOSIS AND MYOMA.
Georgian Med News
October 2024
Azerbaijan Medical University, Department of Obstetrics and Gynecology II, Baku, Azerbaijan.
The Aim Of The Study: to examine the pathomorphological and clinical characteristics of the uterus in the combined form of fibroids and adenomyosis.
Methods: The research work was conducted within the framework of the scientific program of the Department of Obstetrics and Gynecology II at Azerbaijan Medical University for the years 2021-2024. In the course of this study, a comprehensive clinical, laboratory, and instrumental prospective examination was conducted on 113 patients aged 30 to 50 years (mean age 42,0±1,8 years) with combined adenomyosis and uterine fibroids.
An Exploration of How Medication-Assisted Treatment Employees Respond to Stress in Justice Settings.
J Correct Health Care
December 2024
Department of Justice, Law and Criminology, American University, Washington, District of Columbia, USA.
Individuals who work in medication-assisted treatment (MAT) programs that serve justice-involved populations face challenging conditions that can cause elevated levels of stress. Although some studies focus on stress faced by MAT professionals, few examine their coping mechanisms. This study applies the Mayo Clinic's "4A's" of stress management-accept, adapt, avoid, and alter-to better understand ways medical staff working in MAT programs manage stress.
View Article and Find Full Text PDFRestoring adapter protein complex 4 function with small molecules: an in silico approach to spastic paraplegia 50.
Protein Sci
January 2025
Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
This study focuses on spastic paraplegia type 50 (SPG50), an adapter protein complex 4 deficiency syndrome caused by mutations in the adapter protein complex 4 subunit mu-1 (AP4M1) gene, and on the downstream alterations of the AP4M1 protein. We applied a battery of heterogeneous computational resources, encompassing two in-house tools described here for the first time, to (a) assess the druggability potential of AP4M1, (b) characterize SPG50-associated mutations and their 3D scenario, (c) identify mutation-tailored drug candidates for SPG50, and (d) elucidate their mechanisms of action by means of structural considerations on homology models of the adapter protein complex 4 core. Altogether, the collected results indicate R367Q as the mutation with the most promising potential of being corrected by small-molecule drugs, and the flavonoid rutin as best candidate for this purpose.
View Article and Find Full Text PDFSensitivity of bulk electrical impedance spectroscopy (bio-capacitance) probes to cell and culture properties: Study on CHO cell cultures.
Biotechnol Prog
December 2024
Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, Manitoba, Canada.
Bulk electrical impedance spectroscopy (bio-capacitance) probes, hold significant promise for real-time cell monitoring in bioprocesses. Focusing on Chinese hamster ovary (CHO) cells, we present a sensitivity analysis framework to assess the impact of cell and culture properties on the complex permittivity spectrum, ε, and its associated parameters, permittivity increment, Δε, critical frequency, f, and Cole-Cole parameter, α, measured by bio-capacitance probes. Our sensitivity analysis showed that Δε is highly sensitive to cell size and concentration, making it suitable for estimating biovolume during the exponential growth phase, whereas f provides information about cumulative changes in cell size, membrane permittivity, and cytoplasm conductivity during the transition to death phase.
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