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| http://dx.doi.org/10.1016/j.biopsych.2022.06.023 | DOI Listing |
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A Novel Statistical Method for Unmasking Sex-Specific Genomics Signatures in Complex Traits.
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CERVO Brain Research Centre, Québec City, Québec, Canada.
Genotype-phenotype association studies have advanced our understanding of complex traits but often overlook sex-specific genetic signals. The growing awareness of sex-specific influences on human traits and diseases necessitates tailored statistical methodologies to dissect these genetic intricacies. Rare genetic variants play a significant role in disease development, often exhibiting stronger per-allele effects than common variants.
View Article and Find Full Text PDFUnmasking herpes encephalitis masquerading as acute psychosis via neuroimaging.
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Department of General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, India.
Psychosis is a complex mental health condition that can have a profound impact on individuals and their families. It is characterized by a loss of contact with reality, including delusions, hallucinations, and disorganized thinking. While psychosis is most commonly associated with psychiatric disorders such as schizophrenia, it is crucial to consider other potential causes to ensure accurate diagnosis and appropriate treatment.
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The Third Hospital of Mianyang, Sichuan Mental Health Center, Sichuan Province, China. Electronic address:
Background: There is an unmet need for stand-alone digital therapeutics for cognitive impairment in schizophrenia. This study aimed to evaluate the efficacy and acceptability of a novel digital therapeutic, IBT-SC02, for cognitive impairment in stable schizophrenia patients.
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Clozapine-Related Functional Bowel Obstruction: A Rare Adverse Effect Unmasking Quetiapine and Benztropine Interaction Raising Need for Bowel Surveillance.
ACG Case Rep J
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Department of Internal Medicine, Michigan State University, Garden City Hospital, Garden City, MI.
Randomized controlled trials demonstrate a significant decline in hospital admissions and length of stay following the initiation of clozapine in individuals with bipolar disorder and schizophrenia, along with an increase in quality-adjusted life years. The morbidity and mortality associated with clozapine-induced gastrointestinal hypomotility (CIGH) is greater than agranulocytosis. Despite this, we only have clozapine risk evaluation and mitigation strategies by the US Food and Drug Administration for white cell count monitoring, but none exists for CIGH.
View Article and Find Full Text PDFInhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia.
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Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Hypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural oscillations, those above 30 Hz (i.e.
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