Poverty-like all life experiences-can change the developing brain. Psychopathology can, too. But how? And when? And why? And what happens to brain development when children face both poverty and pathology at the same time? With 1 in 5 children growing up poor in the United States today-each at higher risk for developing depression-answering these questions remains among public mental health's most important imperatives. Yet doing so is wickedly challenging: investigators must decipher a wide array of interacting social and biological processes.
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http://dx.doi.org/10.1016/j.jaac.2022.08.006 | DOI Listing |
Front Neural Circuits
January 2025
Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania "Luigi Vanvitelli", Naples, Italy.
The substantia nigra pars compacta (SNc), one of the main dopaminergic nuclei of the brain, exerts a regulatory function on the basal ganglia circuitry via the nigro-striatal pathway but its possible dopaminergic innervation of the thalamus has been only investigated in non-human primates. The impossibility of tract-tracing studies in humans has boosted advanced MRI techniques and multi-shell high-angular resolution diffusion MRI (MS-HARDI) has promised to shed more light on the structural connectivity of subcortical structures. Here, we estimated the possible dopaminergic innervation of the human thalamus via an MS-HARDI tractography of the SNc in healthy human young adults.
View Article and Find Full Text PDFFront Syst Neurosci
January 2025
International research center for Cognitive Applied Neuroscience (IrcCAN), Università Cattolica del Sacro Cuore, Milan, Italy.
This study examines the impact of positive and negative feedback on recall of past decisions, focusing on behavioral performance and electrophysiological (EEG) responses. Participants completed a decision-making task involving 10 real-life scenarios, each followed by immediate positive or negative feedback. In a recall phase, participants' accuracy (ACC), errors (ERRs), and response times (RTs) were recorded alongside EEG data to analyze brain activity patterns related to recall.
View Article and Find Full Text PDFConstraints
November 2024
Polytechnique Montréal, Montreal, Canada.
Constraint programming is known for being an efficient approach to solving combinatorial problems. Important design choices in a solver are the , designed to lead the search to the best solutions in a minimum amount of time. However, developing these heuristics is a time-consuming process that requires problem-specific expertise.
View Article and Find Full Text PDFFront Neural Circuits
January 2025
Department of Neurobiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
A strong repetitive stimulus can occasionally enhance axonal excitability, leading to the generation of afterdischarge. This afterdischarge outlasts the stimulus period and originates either from the physiological spike initiation site, typically the axon initial segment, or from ectopic sites for spike generation. One of the possible mechanisms underlying the stimulus-induced ectopic afterdischarge is the local depolarization due to accumulated potassium ions surrounding the axonal membranes of the distal portion.
View Article and Find Full Text PDFFront Comput Neurosci
January 2025
Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
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