Purpose/objective: To analyze dose-volume histogram (DVH)-derived data on the exposure of organs at risk with impact on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients at 6 and 12 months after definitive or adjuvant (chemo)radiotherapy.
Materials And Methods: Sixty-one patients were prospectively treated with (chemo)radiotherapy. Prophylactic or reactive gastrostomy tube placement was performed in 41 (67.2%) patients. Dose-volume histogram parameters were obtained for the swallowing apparatus.
Results: Median follow-up time was 25 (2-34) months. Overall survival was shorter in patients with inlying PEG tubes at 6 and 12 months (log rank p = 0.038 and p = 0.017) after therapy completion. The estimated median time of tube dependency was 6 (95% confidence interval: 2-14) months. After 6 months, 46.5% of patients were tube dependent. After 12 months, this estimated proportion fell to 31.5%. For both time points, the volume to the larynx (in %) receiving at least 50 Gy (larynx V50Gy) exceeding 53% was predictive for long-term tube feeding (6 months: p = 0.041 and 12 months: p = 0.042) being an independent predictor during multivariable analysis. There was no clinical feature influencing tube dependence after 12 months.
Conclusion: Long-term gastrostomy dependence was found to be strongly associated with an exposure of laryngeal structures (specifically, V50Gy ≥ 53%) during radiotherapy. Consequently, the avoidance of supraglottic as well as glottic structures is warranted.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581845 | PMC |
| http://dx.doi.org/10.1007/s00066-022-01992-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-case evaluation of oral feeding intervention and gastrostomy tube fading in adults with intellectual and multiple disabilities.
J Intellect Dev Disabil
March 2024
Clinical and Professional Development, Melmark New England, Andover, MA, USA.
Background: Some adults with intellectual disabilities do not acquire oral feeding skills and are dependent on gastrostomy tube supplementation.
Methods: Two adults with intellectual and multiple disabilities received intervention for oral consumption during daily meals (standardised food and liquid quantities, individualised procedural guidelines, and consumption-contingent consequences) while the frequency and amount of gastrostomy tube feedings were gradually decreased and eliminated.
Results: Compared to baseline (pre-intervention) conditions, the adults increased oral consumption of food and liquid during the intervention and gastrostomy tube supplementation was eliminated.
Orientation-Dependent Anisotropic Desalination by Assembled Zeolite Nanotube Membranes.
Langmuir
January 2025
College of Physical Science and Technology, Yangzhou University, Yangzhou 225002, China.
Porous nanomaterials have shown great promise in many desalination applications. Zeolite nanotubes, featuring abundant but inhomogeneous nanopores on their surface, have been recently synthesized in experiments; however, their capacity for desalination is not yet understood. In this work, we use molecular dynamics simulations to investigate the capability of assembled zeolite nanotube membranes to perform in desalination applications due to their inherent multiscale porous properties.
View Article and Find Full Text PDFAnticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis.
Discov Oncol
January 2025
Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Objectives: Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant tumors. Therefore, we investigated the anticancer and antiangiogenic effects of LEF on oral squamous cell carcinoma (OSCC).
Methods: To evaluate the inhibitory effect of LEF on OSCC, cell proliferation and wound-healing assays using human OSCC cell lines were performed.
Structural insights into the recognition of RALF peptides by FERONIA receptor kinase during Brassicaceae pollination.
Plant Mol Biol
January 2025
Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gujarat, 382355, India.
Ensuring species integrity and successful reproduction is pivotal for the survival of angiosperms. Members of Brassicaceae family employ a "lock and key" mechanism involving stigmatic (sRALFs) and pollen RALFs (pRALFs) binding to FERONIA, a Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) receptor, to establish a prezygotic hybridization barrier. In the absence of compatible pRALFs, sRALFs bind to FERONIA, inducing a lock state for pollen tube penetration.
View Article and Find Full Text PDFRisk factors for the occurrence of arytenoid dislocation after major abdominal surgery: A retrospective study.
Medicine (Baltimore)
November 2024
Department of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
The incidence of arytenoid dislocation in abdominal surgery is relatively high, the cause is unknown, and it has not received sufficient attention. To identify the risk factors of arytenoid dislocation after abdominal surgery, and to establish a clinical prediction model based on relevant clinicopathological characteristics. We retrospectively collected the clinical data of 50 patients with arytenoid dislocation (AD) and 200 patients without AD after abdominal surgery with general anesthetic tracheal intubation in our Hospital from January 2013 to December 2019.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!