AI Article Synopsis
- The study assessed venom differences from rattlesnakes in three Colombian ecoregions: Magdalena Medio, Caribe, and Orinoquía, finding variations in composition and effects.
- All venoms contained common components like proteases and phospholipase A, but only the Caribe venom had crotamine, while Magdalena Medio showed the highest overall biological activity.
- Notable differences were also observed in how each venom responded to commercial antivenoms, indicating variability in effectiveness, alongside significant intraspecific variation in venom component abundance and activity.
Article Abstract
Biochemical and biological differences in the venom of from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three regionally distributed venoms contain proteases, PLAs and the basic subunit of crotoxin. However, only crotamine was detected in the CA venom. The highest lethality, coagulant, phospholipase A and hyaluronidase activities were found in the MM venom. Also, some differences, observed by western blot and immunoaffinity, were found in all three venoms when using commercial antivenoms. Furthermore, all three eco-regional venoms showed intraspecific variability, considering the differences in the abundance and intensity of their components, in addition to the activity and response to commercial antivenoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416679 | PMC |
| http://dx.doi.org/10.3390/toxins14080532 | DOI Listing |
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