AI Article Synopsis
- Four new compounds, including three andrastin-type meroterpenoids (hemiacetalmeroterpenoids A-C) and a drimane sesquiterpenoid (astellolide Q), were isolated from the marine-derived fungus sp. N-5, along with eleven known compounds.
- The structures of these new compounds were determined using detailed spectroscopic analysis, and their absolute configurations were confirmed through ECD spectra comparison.
- Hemiacetalmeroterpenoid A features a unique 6,6,6,6,5,5 hexa-cyclic skeleton and showed significant antimicrobial activity, with MIC values between 1.56 and 6.25 μg/mL against certain bacteria.
Article Abstract
Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (-), and a drimane sesquiterpenoid astellolide Q (), together with eleven known compounds (-) were isolated from the cultures of the marine-derived fungus sp. N-5, while compound was first isolated from a natural source. The structures of the new compounds were determined by analysis of detailed spectroscopic data, and the absolute configurations were further decided by a comparison of the experimental and calculated ECD spectra. Hemiacetalmeroterpenoid A () possesses a unique and highly congested 6,6,6,6,5,5-hexa-cyclic skeleton. Moreover, the absolute configuration of compound was also reported for the first time. Compounds , and exhibited significant antimicrobial activities against and with MIC values ranging from 1.56 to 6.25 μg/mL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410149 | PMC |
| http://dx.doi.org/10.3390/md20080514 | DOI Listing |
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Hemiacetalmeroterpenoids A-C and Astellolide Q with Antimicrobial Activity from the Marine-Derived Fungus sp. N-5.
Mar Drugs
August 2022
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Article Synopsis
- Four new compounds, including three andrastin-type meroterpenoids (hemiacetalmeroterpenoids A-C) and a drimane sesquiterpenoid (astellolide Q), were isolated from the marine-derived fungus sp. N-5, along with eleven known compounds.
- The structures of these new compounds were determined using detailed spectroscopic analysis, and their absolute configurations were confirmed through ECD spectra comparison.
- Hemiacetalmeroterpenoid A features a unique 6,6,6,6,5,5 hexa-cyclic skeleton and showed significant antimicrobial activity, with MIC values between 1.56 and 6.25 μg/mL against certain bacteria.
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