AI Article Synopsis
- The study focused on the impact of TDP-43 protein on the shape (deformation) of the hippocampus in the brain.
- It found that higher levels of TDP-43 were linked to inward changes in the hippocampal structure.
- These changes were also related to cognitive performance, indicating TDP-43 has a unique role in influencing both brain structure and function.
Article Abstract
• We explored TDP-43 burden and hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with cognition scores.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421500 | PMC |
| http://dx.doi.org/10.1016/j.nicl.2022.103125 | DOI Listing |
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