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Peritoneal Dissemination and Malignant Ascites in Duodenal Cancer Successfully Treated With Adoptive Cell Therapy Using WT1- and MUC1-Pulsed Dendritic Cells and Activated T Cells With No Adverse Effects: A Case Report.
Cureus
November 2024
Department of Immunotherapy, Bio-Thera Clinic, Tokyo, JPN.
A satisfactory treatment for the dissemination of duodenal cancer has not yet been established. We describe a case of peritoneal dissemination and malignant ascites in duodenal cancer that was successfully treated with adoptive cell therapy with no adverse effects. A 72-year-old Japanese male patient with primary duodenal cancer with distal lymph node metastases received chemotherapy with S-1, an oral pyrimidine fluoridederived agent, and oxaliplatin after gastrojejunal bypass, which resulted in tumor shrinkage; however, peritoneal dissemination developed.
View Article and Find Full Text PDFTopological Data Analysis of Ninjin'yoeito Effects Unraveling Complex Interconnections in Patients With Frailty: A Pilot Study.
Cureus
November 2024
Urogynecology, Yokosuka Urogynecology and Urology Clinic, Yokosuka, JPN.
Background Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine, has shown potential in treating frailty and overactive bladder (OAB) symptoms. However, its effects are multifaceted and vary among individuals. This pilot study explored the use of topological data analysis (TDA) and natural language processing (NLP) to evaluate the effect of NYT on frailty in patients with OAB.
View Article and Find Full Text PDFAssociations Between Non-Verbal Cognitive Assessment and Stroke Recovery via Screening Test for Aphasia and Dysarthria.
J Stroke Cerebrovasc Dis
December 2024
Research Center for Child Mental Development, Chiba University, Chiba 260-8670, Japan. Electronic address:
Objective: Non-verbal Screening Test for Aphasia and Dysarthria scores correlate with post-stroke cognitive function; however, their correlations with activities of daily living dependency and home discharge (cognitive function-associated outcomes) remain unclear. We investigated the correlation of these scores with activities of daily living dependency and home discharge outcomes.
Materials And Methods: Disability levels and functional outcomes of 278 inpatients with brain injury (age: 72.
Natural selection shapes codon usage and host adaptation of NS1 in mosquito-borne pathogenic flaviviruses.
Int J Biol Macromol
December 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:
The NS1 protein of nine mosquito-borne flaviviruses, including Dengue virus 1-4, Japanese encephalitis virus, West Nile virus, Yellow fever virus, Tembusu virus, and Zika virus, shows distinct codon usage and evolutionary traits. Codon usage analysis shows notable base composition bias and non-conservatism in NS1, with distinct evolutionary traits from its ORF. Analysis of relative synonymous codon usage (RSCU) indicates that the NS1 genes exhibit non-conservative RSCU patterns within different mosquito-borne pathogenic flaviviruses.
View Article and Find Full Text PDFInvestment strategies for sustainable safe development of Chinese coal mine employees driven by digital intelligence.
Front Public Health
December 2024
School of Economics and Management, Huainan Normal University, Huainan, China.
China's "14th Five-Year Plan" proposes the construction of a "Digital China," posing the challenge of digital transformation to coal mining enterprises. It is critical to compare the effectiveness of investing in digital devices with that of human capital. This study establishes a structural equation model based on the 'regulation-situation-behavior' theoretical framework.
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