This paper analyzes the influence of the overlying extremely thick primary key stratum on the strong mine pressure hazard at the large mining face in Gaojiapu coal mine. The analysis of the distribution characteristics of the primary key stratum in the Gaojiapu coal mine reveals the bow-shaped structural characteristics of the overlying thick primary key stratum. An elastodynamic model was developed using the variational method to calculate and analyze the influence of the movement of the primary key stratum on the stress and energy of the underlying weak rock. The results show that the arch structure of the overlying extremely thick primary key stratum can significantly affect the distribution pattern of stress and strain energy in the coal body, and the stress and strain energy in the coal body are transferred to the middle of the coal column, and the middle region of the coal column enters a high stress state. These results suggest that the change in thickness of the overlying primary key stratum at Gaojiapu in the coal column area is a major factor in the frequent occurrence of impact ground pressure events at the mine. This study explains the causes of frequent impact ground pressure in the lower coal rock mass of the extremely thick primary key stratum, and provides a reference for the prevention and control of impact hazards in the extremely thick primary key stratum.
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http://dx.doi.org/10.1038/s41598-022-18641-7 | DOI Listing |
Pharmaceutics
December 2024
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due to their excellent biocompatibility, high drug-loading capacity, and tunable drug-release properties. This review systematically examines the matrix materials and fabrication methods of HMN systems, highlighting advancements in natural and synthetic polymers, and explores their applications in treating conditions such as wound healing, hair loss, cardiovascular diseases, and cancer.
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January 2025
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Safe and effective treatments for psoriasis are limited. Anisole is an active ingredient in citrus and basil volatile oils; however, its potential for psoriasis treatment remains unexplored. To investigate the effects and mechanism of anisole transdermal administration as a treatment for psoriasis.
View Article and Find Full Text PDFSci Rep
January 2025
School of Energy and Mining Engineering, China University of Mining and Technology (Beijing), Beijing, 100083, China.
For a long time, the management of surface structures such as villages and rivers affected by underground coal mining has been a popular and difficult issue in coal mining. With the further tightening of environmental protection requirements, it has become challenging for some underground coal mines that lack the conditions for filling and grouting to ensure the recovery of coal resources while controlling surface subsidence. Furthermore, many such common issues have emerged in the Yushen and Binchang mining areas of Shanxi Province, as well as in several other coalfields, severely constraining the development of coal energy and ecological environmental protection.
View Article and Find Full Text PDFZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
December 2024
Laboratory of Occupational Protection and Ergonomics, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
To analyze the distribution characteristics of work-related musculoskeletal disorders (WMSDs) among the occupational population in China's key industries during the period from 2018 to 2023, and to provide data support for the formulation of targeted prevention strategies. Between January 1, 2018, and December 31, 2023, a cross-sectional epidemiological survey and a retrospective investigation were conducted in seven geographical regions of North China, East China, Central China, South China, Southwest China, Northwest China, and Northeast China, using a combination of epidemiological cross-sectional and retrospective surveys. The industries were stratified according to the degree of closeness to WMSDs, the size of the occupational population, and the importance of the national economy, and then cluster sampling was conducted according to the size of the enterprises (large, medium, and small) within each stratum.
View Article and Find Full Text PDFPLoS One
December 2024
Railway Engineering Research Institute, China Academy of Railway Sciences Co. Ltd, Beijing, China.
Splitting grouting is widely used to reinforce unfavorable soil stratum. Inclined steel grouting pipe is a type of structure which can achieve splitting grouting in soil stratum. It has been successfully utilized in argillaceous sandstone stratum, but its application in loess stratum has rarely been studied directly.
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