Background: SMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) is a rare primary lung malignancy. These diseases are not listed separately in the 2021 World Health Organization (WHO) classification of lung neoplasms, but they have special morphological, immunophenotypic and molecular genetic characteristics. This study aims to improve understanding of SMARCA4-dNSCLC by discussing the clinicopathological features, diagonosis and differential diagnosis of the disease.
Methods: The clinical and imaging data of 9 cases of SMARCA4-dNSCLC diagnosed in Shanghai Changhai Hospital from January 2020 to March 2022 were collected. The clinicopathological features were analyzed by histological and immunohistochemical staining, and the literature was reviewed.
Results: The median age of 9 patients was 65 years old. Six men were smokers. The average maximum diameter of tumor was 3.3 cm. Six cases had been metastasized. The imaging showed that it was an infiltrating mass with unclear boundary and 3 cases invaded the pleura. Nine cases were diagnosed as SMARCA4-dNSCLC, which mainly showed three pathological forms including classic lung adenocarcinoma, mucinous adenocarcinoma and poorly differentiated carcinoma. Poorly differentiated tumor cells are epithelioid, syncytial or rhabdomyoid, the cytoplasm was rich, the cytoplasm could be completely transparent to eosinophilic, eosinophilic globules or small abscesses could be seen, showing solid flakes, with more inflammatory cells and flake necrosis in the stroma. Immunohistochemistry showed that SMARCA4 was negative in all cases and eight cases demonstrated cytokeratin 5.2 (CAM5.2) and cytokeratin 7 (CK7) was diffusely strongly positive, p40 was negative, thyroid transcription factor-1 (TTF-1) was negative in 6 cases, partially positive in 2 cases and diffusely positive in 1 case.
Conclusions: SMARCA4-dNSCLC is a rare subtype of lung cancer with complex and diverse pathological morphology. The characteristic of immunohistochemical phenotype can assist in the diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411953 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.27 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Abdominal PP meshes coated with functional core-sheath biodegradable nanofibers with anticoagulant and antibacterial properties.
Biomater Adv
January 2025
Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207 - UMET - Unité Matériaux et Transformations, F-59000 Lille, France. Electronic address:
Abdominal hernia repair is a common surgical procedure, involving in most cases the use of textile meshes providing a mechanical barrier to consolidate the damaged surrounding tissues and prevent the resurgence of the hernia. However, in more than half cases postoperative complications such as adhesions and infections occur at the surface of the mesh, leading to chronic pain for the patient and requiring the removal of the implant. One of the most promising strategies to reduce the risk of postoperative adhesions and infections is to add a physical barrier between the mesh and the abdominal walls.
View Article and Find Full Text PDFBGCSL: An unsupervised framework reveals the underlying structure of large-scale whole-brain functional connectivity networks.
Comput Methods Programs Biomed
January 2025
Shanghai Maritime University, Shanghai 201306, China. Electronic address:
Background And Objective: Inferring large-scale brain networks from functional magnetic resonance imaging (fMRI) provides more detailed and richer connectivity information, which is critical for gaining insight into brain structure and function and for predicting clinical phenotypes. However, as the number of network nodes increases, most existing methods suffer from the following limitations: (1) Traditional shallow models often struggle to estimate large-scale brain networks. (2) Existing deep graph structure learning models rely on downstream tasks and labels.
View Article and Find Full Text PDFMultiple secondary stabiliser injuries increase rotational instability in anterior cruciate ligament-deficient knees.
Knee Surg Sports Traumatol Arthrosc
January 2025
Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Purpose: Medial meniscus ramp lesions (MMRLs), lateral meniscus posterior root tears (LMPRTs), and anterolateral complex injuries (ALCIs) are major secondary stabiliser injuries associated with anterior cruciate ligament (ACL) injuries. This study aimed to investigate the effect of the number of secondary stabiliser injuries on knee instability in ACL injuries.
Methods: Patients who underwent primary ACL reconstruction between January 2017 and May 2023 were enroled in this study.
National and Regional Trends in Congenital Cytomegalovirus Infection From 1998 to 2019.
Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Objective: To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.
Study Design: Cross-sectional study.
Setting: National Inpatient Sample (NIS) database.
Antireflux surgery - choosing the right candidate.
Expert Rev Gastroenterol Hepatol
January 2025
Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Introduction: Surgical gastric fundoplication is an effective treatment option for gastroesophageal reflux disease. In contrast to acid suppression, fundoplication nearly abolishes all types of reflux, acid and nonacid. However, in some cases lasting side effects of the procedure may overshadow its positive effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!