AI Article Synopsis
- A new cytotoxic alkaloid called streptothiazolidine B was discovered, alongside three other known compounds, from a specific source.
- The structure of streptothiazolidine B was determined using advanced techniques like 1D and 2D NMR, HRESIMS, NOESY experiments, and ECD analysis, confirming it as an amide alkaloid with a unique side chain.
- Streptothiazolidine B showed strong cytotoxic effects on human tumor cell lines Li-7 and A2780, with IC values of 7.8 and 9.1 μM, while another compound exhibited cytotoxicity against four different tumor cell lines with IC values ranging from
Article Abstract
A new cytotoxic alkaloid, named streptothiazolidine B (), together with three known compounds (-), were isolated from . The structure of the undescribed compound was established using 1D and 2D NMR, and HRESIMS. Streptothiazolidine B was isolated and identified as an amide alkaloid with a unique thiazolidine side chain and its absolute configuration was determined by a combination of NOESY experiment and ECD analysis. Streptothiazolidine B exhibited significant cytotoxic activities against two human tumor cell lines, Li-7 and A2780, with IC values of 7.8, and 9.1 μM. Meanwhile, compound showed obvious cytotoxic activities against four human tumor cell lines, THP-1, HT29, Li-7 and A2780, with IC values ranging from 3.1 to 10.2 μM.
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| http://dx.doi.org/10.1080/10286020.2022.2111679 | DOI Listing |
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