Malondialdehyde (MDA) is a product of lipid peroxidation that is often determined in abiotic stress-related phytoremediation research. This study assessed (July 14, 2022) the frequency of eight nomenclatural forms of MDA between 2001 and 2021 using three major databases (PubMed, Scopus, and Web of Science (WoS9). The most common form (75,060, 57,874, and 65,663 times in PubMed, Scopus, and WoS, respectively) of MDA was "malondialdehyde", followed by "malonaldehyde" (68,240, 3815, and 2337 times in these three databases, respectively). According to WoS, the journals that used "malondialdehyde" and "malonaldehyde" most frequently were (Springer-Nature) (587 times) and (AIP Publishing) (57 times). Other less-frequent forms were: malonyldialdehyde, malonic dialdehyde, malon-dialdehyde, malone dialdehyde, malonic aldehyde, and malonodialdehyde. We recommend that the editors of journals that publish papers with themes that are closely associated with plant stress specify in their instructions for authors their journal's preferable nomenclatural form of MDA. The plant abiotic stress community, including phytoremediation specialists, need to debate this topic with the objective of seeking a standardized nomenclatural form of MDA, which would help to fortify the integrity of searches in major databases by allowing all relevant literature to be accurately identified. Malondialdehyde (MDA), a product of lipid peroxidation that is often determined in stress-related phytoremediation research, has various forms to its name. These nomenclatural variations were assessed in PubMed-, Scopus-, and Web of Science-indexed literature. This is the first study to detect, report, quantify and debate these forms of MDA.
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http://dx.doi.org/10.1080/15226514.2022.2106184 | DOI Listing |
Drug Des Devel Ther
January 2025
Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
Introduction: The mechanism of remimazolam, a benzodiazepine that activates γ-aminobutyric acid a (GABAa) receptors, in cerebral ischemia/reperfusion (I/R) injury is not well understood. Therefore, we explored whether remimazolam activates protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β)/nuclear factor erythroid 2-related factor 2 (NRF2) to attenuate brain I/R injury in transcerebral I/R-injured rats and transoxygenic glucose deprivation/reperfusion (OGD/R)-injured SY5Y cells.
Material And Methods: Remimazolam was added at the beginning of cell and rat reperfusion, and the PI3K/AKT inhibitor LY294002 was added to inhibit the AKT/GSK-3β/NRF2 pathway 24 h before cellular OGD/R treatment and 30 min before rat brain I/R treatment.
J Biophotonics
January 2025
Faculty of Medicine, Department of Biophysics, Yuksek Ihtisas University, Ankara, Türkiye.
Zerumbone is a sesquiterpene phytochemical with cytotoxic activity against cancer. This study aimed to evaluate the effect of zerumbone on cell viability by WST-1 test, apoptosis by TUNEL, lipid peroxidation markers (malondialdehyde, MDA, and 4-hydroxynonenal, HNE) by using assay kits, and biomolecular changes by ATR-FTIR spectroscopy in A549 cells. After zerumbone (0-100 μM) incubation for 24, 48, and 72 h, the number of TUNEL-positive cells was found to be higher in zerumbone-treated cells than in controls, in consistent with cell morphology results.
View Article and Find Full Text PDFBMC Pulm Med
January 2025
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, 7618868367, Iran.
Background: Paraquat (PQ) is a widely used pesticide, can cause severe intoxication and respiratory failure. Myrtenol (Mrl), an essential oil derived in various plants, exhibits several biological properties, including anti-inflammatory and antioxidant activities. This study aims to investigate the protective potential of Mrl against oxidative stress and inflammation caused by PQ exposure.
View Article and Find Full Text PDFThis study primarily investigated the mechanism of Astragalus polysaccharides(APS), a Chinese medicinal material, in regulating the Nrf2/SLC7A11/GPX4 signaling pathway to induce ferroptosis in ovarian cancer cells(Caov-3 and SKOV3 cells). Caov-3 and SKOV3 cells were divided into control(Vehicle) group, APS group, glutathione peroxidase 4 inhibitor(RSL3) group, and APS+RSL3 group. After 48 h of intervention, the activity and morphology of the cells in each group were observed.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
December 2024
School of Medicine, Jianghan University Wuhan 430056, China.
This study aims to investigate the mechanism of tanshinone Ⅱ_A(Tan Ⅱ_A) in protecting mice from diethylinitrosamine(DEN)/carbon tetrachloride(CCl_4)/ethanol(C_2H_5OH)-induced hepatocellular carcinoma(HCC) and HepG2 cells from hydrogen peroxide(H_2O_2)-induced oxidative damage via the phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt) and nuclear factor E2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) signaling pathways. Sixty male C57BL/6J mice were grouped as follows: control, model, low, medium, and high-dose(10, 20, 40 mg·kg~(-1), respectively) Tan Ⅱ_A, and colchicine(0.2 mg·kg~(-1)), with 10 mice in each group.
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