AI Article Synopsis
- The study analyzed clinical data from 1,958 head and neck cancer patients to examine paraneoplastic syndromes (PNS) and their impact on diagnosis and prognosis.
- Out of these, 40 patients had PNS, primarily dermatologic, with a mean age of 60.4 years, and the majority were in advanced cancer stages (III/IV).
- Results indicated that early detection of PNS was associated with better overall survival and disease-free survival rates, highlighting the importance of recognizing these syndromes for improving patient outcomes.
Article Abstract
Background: To summarize the clinical manifestations, diagnosis, and prognosis of head and neck cancer (HNC) patients with paraneoplastic syndromes (PNS).
Methods: The clinical data of 1958 patients with HNC admitted to our hospital from January 1996 to December 2020 were retrospectively analyzed. Demographic and cancer-related characteristics were extracted. Kaplan-Meier survival curves were compared by log-rank test. Cox regression was performed to evaluate prognostic factors and hazard ratio.
Results: Totally 40 HNC patients with PNS were included in the final analysis, including 36 men and four women with a mean age of 60.4 years (range 40-82). PNS was dermatologic or cutaneous in 23 (57.50%) patients, endocrine in 10 (25.00%), neurologic in five (12.50%), and osteoarticular or rheumatologic in two (5.00%). Twenty-five (62.50%) patients had Stage III/IV cancer. PNS regressed after antitumor therapy in 28 (70.00%) patients. Recurrence of PNS was observed in nine of 12 (75.00%) patients with cancer recurrence or metastasis. The 5-year overall survival (OS) and disease-free survival (DFS) rates of patients with PNS were 51.52% and 44.44%, respectively. The DFS ( = .001) and OS ( = .003) of patients presented with PNS prior to HNC diagnosis were significantly longer than those of patients with synchronous or metachronous PNS. PNS diagnosed before HNC (adjusted hazard ratio [aHR]: 0.31, 95% confidence interval [CI]: 0.11-0.85, = .02), Stage IV disease (aHR: 3.27, 95% CI: 1.18-9.05, = .02), and smoking history (aHR: 3.69, 95% CI: 1.04-13.05, = .04) were significantly associated with OS and DFS.
Conclusions: Early recognition of PNS could provide clues about underlying tumor condition and result in early diagnosis. Prompt detection of cancer-associated syndromes could lead to a more favorable prognosis for these patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392377 | PMC |
| http://dx.doi.org/10.1002/lio2.849 | DOI Listing |
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