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High-Throughput Effect-Directed Analysis of Androgenic Compounds in Hospital Wastewater: Identifying Effect Drivers through Non-Target Screening Supported by Toxicity Prediction.
Environ Sci Technol
January 2025
Department Exposure Science, Helmholtz Centre for Environmental Research─UFZ, 04318 Leipzig, Germany.
The increasing number of contaminants released into the environment necessitates innovative strategies for their detection and identification, particularly in complex environmental matrices like hospital wastewater. Hospital effluents contain both natural and synthetic hormones that might significantly contribute to endocrine disruption in aquatic ecosystems. In this study, HT-EDA has been implemented to identify the main effect-drivers (testosterone, androsterone and norgestrel) from hospital effluent using microplate fractionation, the AR-CALUX bioassay and an efficient data processing workflow.
View Article and Find Full Text PDFProtective effects of resveratrol and naringenin against nonylphenol-induced oxidative stress in rats.
AMB Express
January 2025
Plant Protection Department, Faculty of Agriculture, Beni-Suef University, Beni-Suef, 62511, Egypt.
Nonylphenol (NP) is a ubiquitous environmental endocrine disrupting chemical and oxidative stress inducer in biological systems. Resveratrol (RES) and Naringenin (NG) are phytochemicals possessing antioxidant properties and estrogenic activity. This study was conducted to investigate the toxicity of NP and the mitigating effects of RES and NG on NP toxicity in rats.
View Article and Find Full Text PDFImpact of Endocrine Disruptors on Key Events of Hepatic Steatosis in HepG2 Cells.
Food Chem Toxicol
January 2025
RECETOX, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic. Electronic address:
Endocrine-disrupting compounds (EDCs) may contribute to the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the potential of 10 environmentally relevant EDCs to affect key events of hepatic steatosis in HepG2 human hepatoma cells. Increased lipid droplet formation, a key marker of steatosis, was induced by PFOA, bisphenol F, DDE, butylparaben, and DEHP, within the non-cytotoxic concentration range of 1 nM-25 μM.
View Article and Find Full Text PDFPhthalates in the environment of China: A scoping review of distribution, anthropogenic impact, and degradation based on meta-analysis.
Ecotoxicol Environ Saf
January 2025
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, PR China. Electronic address:
Phthalates (PAEs) are a group of endocrine-disrupting environmental chemicals (EEDs) that pose significant risks to human health. PAEs are widespread in various environmental media, including air, dust, water, and soil, and are subject to both horizontal and vertical migration. Human activities significantly influence the distribution of PAEs, yet current research on this relationship remains limited.
View Article and Find Full Text PDFUrodele amphibian newt bridges the missing link in evo-devo of the pancreas.
Dev Dyn
January 2025
Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Background: The pancreas exhibits diverse structures and roles across vertebrates. The pancreas has evolved to include both endocrine and exocrine cells, a change that occurred during the transition from fish to amphibian. This event emphasizes the evolutionary significance of amphibians.
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