Volatile chemicals in the environment provide ethologically important information to many animals. However, how animals learn to use this information is only beginning to be understood. This review highlights recent experimental advances elucidating olfactory learning in rodents, ranging from adaptations to the environment to task-dependent refinement and multisensory associations. The broad range of phenomena, mechanisms, and brain areas involved demonstrate the complex and multifaceted nature of olfactory learning.
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http://dx.doi.org/10.1016/j.conb.2022.102623 | DOI Listing |
Alzheimers Dement
December 2024
Neuroscience Institute, NYU Langone Health, NYU Grossman School of Medicine, New York, NY, USA.
Background: The entorhinal cortex and hippocampus are loci of early vulnerability in AD. These areas are crucial for episodic memory processing for space and contexts. The majority of AD model mouse imaging and electrode studies utilize simple tasks such open field and linear track.
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December 2024
Banner Sun Health Research Institute, Sun City, AZ, USA.
Background: Lewy body (LB) diseases can present with overlapping prodromal, cognitive, motor, autonomic or neuropsychiatric symptoms. Intuitively, greater symptom severity should correlate with greater pathological burden, but this has not been consistently shown. LB pathology does not translate to clinical expression in Incidental LB disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Consortium pour l'Identification précoce de la Maladie d'Alzheimer - Québec, Montréal/Québec/Sherbrooke, QC, Canada.
Background: Olfactory identification is impaired in the early stages of Alzheimer's disease (AD), including mild cognitive impairment (MCI). This early sensory impairment could result from several factors such as early cognitive or structural cerebral damages caused by the disease. It is however not clear which factors are contributing the most to the olfactory impairment in older people at risk of developing AD.
View Article and Find Full Text PDFNat Commun
January 2025
Freie Universität Berlin, Institute for Biology and Genetics, Berlin, Germany.
At presynaptic active zones (AZs), scaffold proteins are critical for coordinating synaptic vesicle release and forming essential nanoarchitectures. However, regulatory principles steering AZ scaffold assembly, function, and plasticity remain insufficiently understood. We here identify an additional Drosophila AZ protein, "Blobby", essential for proper AZ nano-organization.
View Article and Find Full Text PDFFront Bioeng Biotechnol
December 2024
School of Intelligent Manufacturing Engineering, Chongqing University of Arts and Sciences, Chongqing, China.
Introduction: Assessing the olfactory preferences of drivers can help improve the odor environment and enhance comfort during driving. However, the current evaluation methods have limited availability, including subjective evaluation, electroencephalogram, and behavioral action methods. Therefore, this study explores the potential of autonomic response signals for assessing the olfactory preferences.
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