As the world grows more interconnected through the flows of people, goods, and information, many challenges are becoming more difficult to address since human needs are increasingly being met through global supply chains. Global shocks (e.g., war, economic recession, pandemic) can severely disrupt these interconnections and generate cascading consequences across local to global scales. To comprehensively evaluate these consequences, it is crucial to use integrated frameworks that consider multiple interconnections and flows among coupled human and natural systems. Here we use the framework of metacoupling (human-nature interactions within as well as across adjacent and distant systems) to illustrate the effects of major global shocks on the evolution of global interconnectedness between the early 1900s and the 2010s. Based on these results we make a few actionable recommendations to reduce the negative impacts of an ongoing global shock, the COVID-19 pandemic, to promote global sustainability.
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http://dx.doi.org/10.1007/s13280-022-01778-0 | DOI Listing |
Sci Rep
January 2025
Division of Genetics, Indian Agricultural Research Institute, New Delhi, India.
With climate change projections indicating an increase in the frequency of extreme heat events and irregular rainfall patterns globally, the threat to global food security looms large. Terminal heat stress, which occurs during the critical reproductive stage, significantly limits lentil productivity. Therefore, there is an urgent need to improve lentil's resilience to heat stress to sustain production.
View Article and Find Full Text PDFBMJ Glob Health
January 2025
School of Public Health, Imperial College London, London, UK.
Introduction: Faced with a backdrop of an increasing chronic disease burden from an ageing global population compounded with rising healthcare costs, health systems are required to implement cost-effective, safe and equitable care through efficient service delivery models. One approach to achieving this is through Starfield's 4Cs of primary healthcare (PHC), which delineates the key attributes of a high-performing PHC system that upholds the pillars of care coordination, first contact of care, continuity of care and comprehensive care. Therefore, this study aims to explore and elucidate the key themes and subthemes related to and extending beyond Starfield's 4Cs of PHC by integrating findings from a comprehensive literature review and a qualitative study.
View Article and Find Full Text PDFInt Urol Nephrol
January 2025
Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.
Purpose: Urinary cytokine changes may serve as biomarkers to assess treatment outcomes for interstitial cystitis/bladder pain syndrome (IC/BPS). This study analyzed the changes in urinary cytokines following various bladder therapies and explored their clinical significance in therapeutic mechanisms.
Methods: A total of 122 patients with IC/BPS treated with platelet-rich plasma (PRP), botulinum toxin-A (BoTN-A), hyaluronic acid (HA), or low-energy shock wave (LESW) were evaluated.
mBio
January 2025
Department of Microbiology, Genetics, & Immunology, Michigan State University, East Lansing, Michigan, USA.
The emergence and global spread of carbapenem-resistant complex species present a pressing public health challenge. Carbapenem-resistant spp. cause a wide variety of infections, including septic shock fatalities in newborns and immunocompromised adults.
View Article and Find Full Text PDFBBA Adv
January 2025
School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
The morbidity and mortality of sepsis remain high. Clinicians lack effective markers to rapidly diagnose sepsis and identify the underlying pathogen infection particularly for patients with candidaemia or cases of culture-negative sepsis where culture-based diagnostics are inadequate. In our search for new lines of potential sepsis biomarkers, we here explore the impact of various classes of infectious agents on the serum -glycome in a septic shock cohort.
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