Genotypes and Haplotypes in the and Genes are Associated With Susceptibility and With Clinicopathological Characteristics in Breast Cancer Patients.

Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in and in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between rs1133683 and rs2240308, and rs7903146 and rs12255372 variants in breast cancer. Peripheral blood samples were obtained from 404 women (202 patients and 202 control females). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology was used to identify the gene variants. The rs2240308 (C > T), and rs7903146 (C > T) and rs12255372 (G > T) variants were associated with breast cancer and with age, TNM stage, and histologic-molecular subtype ( = 0.001). Likewise, the haplotype T-T in the gene (rs7903146-rs12253372) was significantly related with breast cancer (OR = 2.66, 95%, CI = 1.64-4.30, = 0.001). Our data show a link between rs2240308 and rs7903146 and rs12255372 variants in breast cancer, and speculate this may be important in pathogenesis.