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http://dx.doi.org/10.1016/j.jinf.2022.08.015 | DOI Listing |
Biomolecules
December 2024
School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai 264005, China.
The development of a novel strategy for the measurement of SARS-CoV-2 IgG antibodies is of vital significance for diagnosis and effect of vaccination evaluation. In this investigation, an SiO@Au@CDs nanoparticle (NP)-based lateral flow immunoassay (LFIA) strip was fabricated and coupled with a miniaturized fluorimeter. The morphology features and particle sizes of the SiO@Au@CDs NPs were characterized carefully, and the results indicated that the materials possess monodisperse, uniform, and spherical structures.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.
Detection of biomarkers associated with physiological conditions provides critical insights into healthcare and disease management. However, challenges in sampling and analysis complicate the detection and quantification of protein biomarkers within the epidermal layer of the skin and in viscous liquid biopsy samples. Here, we present the "Lab-on-the-Needles" concept, utilizing a microneedle patch-based sensing box (MNP-based SenBox) for mobile healthcare applications.
View Article and Find Full Text PDFACS Appl Bio Mater
December 2024
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
SARS-CoV-2 is a threat to global public health, which requires the development of safe measures to reduce the spread of this coronavirus. Herein, in this study, we prepared and examined potential antiviral agents based on ZnAl-layered double hydroxide (ZnAl-LDH) materials. ZnAl-LDH-based samples were synthesized via a one-pot low-temperature coprecipitation method, which features an ultrathin structure.
View Article and Find Full Text PDFACS Meas Sci Au
December 2024
School of Pharmacy, Faculty of Science, University of Waterloo, 10 Victoria St S A, Kitchener, ON N2G 1C5, Canada.
The COVID-19 outbreak has led to notable developments in point-of-care (POC) diagnostic devices, as they can be valuable resources in identifying and managing the spread of the pandemic. Currently, the majority of techniques demand advanced laboratory equipment and professionals to execute precise, efficient, accurate, and sensitive testing. In this work, we report a new method to significantly enhance the sensitivity of microwave sensing of the SARS-CoV-2 virus by functionalizing the sensor surface using anti-SARS-CoV-2 spike antibody-gold nanoparticle (AuNPs) conjugates.
View Article and Find Full Text PDFImmun Inflamm Dis
December 2024
Department of Medical Laboratory, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Objective: In the past 5 years, a large number of serological assays for large-scale detection of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen emerged. Serological assays for SARS-CoV-2 were needed to support clinical diagnosis and epidemiological investigations. However, there were limited data on the diagnostic accuracy of these serological assays.
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