gene variation associated with climatic conditions in Chinese cattle.

Anim Biotechnol

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.

Published: December 2023

AI Article Synopsis

  • The TRP superfamily, particularly the TRPM4 gene, is linked to heat tolerance in cattle.
  • A specific missense mutation (p. His746Arg) was studied in 19 native Chinese cattle breeds to explore its association with heat tolerance.
  • Analysis revealed significant geographical differences in allele distribution, with the G allele found in cattle from hotter climates, indicating its potential role in heat tolerance adaptation.

Article Abstract

The transient receptor potential (TRP) superfamily has been reported to play an important role in heat tolerance pathways. Based on the Bovine Genome Variation Database and Selective Signatures, a missense mutation (NC_037345.1: c.2237A > G: p. His746Arg) (rs209689836) was identified in the transient receptor potential cation channel subfamily M member 4 () gene, a member of the TRP family, corresponding to heat tolerance. Here, we explored the prevalence of this variant in 19 native Chinese cattle (comprised of 404 individuals) to determine its possible association with heat tolerance in Chinese cattle by using PCR and DNA sequencing. The distribution of alleles of NC_037345.1: c.2237A > G: p. His746Arg displays significant geographical differences across native Chinese cattle breeds, consistent with the distribution of indicine and taurine cattle in China. Additionally, the association analysis indicated that the G allele was significantly associated with mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI) ( < .05), suggesting that cattle carrying allele G were distributed in regions with higher T, RH, and THI. In conclusion, our results suggested that the mutation of the gene in Chinese cattle might be a candidate locus associated with heat tolerance.

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Source
http://dx.doi.org/10.1080/10495398.2022.2112686DOI Listing

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