AI Article Synopsis
- Chronic liver diseases are a major global health concern, necessitating new treatment options alongside liver transplants.
- Recent studies suggest that cell-based therapies could help improve liver function by addressing tissue damage and modulating the immune response.
- This review highlights the progress and challenges of various cell therapies in clinical and animal studies, specifically focusing on mesenchymal stem cells and critical factors like dosage and transfusion methods.
Article Abstract
Chronic liver diseases have become a significant health issue worldwide and urgently require the development of novel therapeutic approaches, in addition to liver transplantation. Recent clinical and preclinical studies have shown that cell-based therapeutic strategies may contribute to the improvement of chronic liver diseases and offer new therapeutic options to restore liver function through their roles in tissue impairment and immunomodulation. In this review, we summarize the current progress and analyze the challenges for different types of cell therapies used in the treatment of chronic liver diseases currently explored in clinical trials and preclinical studies in animal models. We also discuss some critical issues regarding the use of mesenchymal stem cells (MSCs, the most extensive cell source of stem cells), including therapeutic dosage, transfusion routine, and pharmacokinetics/pharmacodynamics (PK/PD) of transfused MSCs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492280 | PMC |
| http://dx.doi.org/10.1093/stcltm/szac053 | DOI Listing |
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