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| http://dx.doi.org/10.1111/jdv.18556 | DOI Listing |
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Exploration of Bogdanov-Takens and Hopf bifurcation through coupling of nonlinear recovery with multiple reinfections of COVID-19.
Chaos
January 2025
Department of Mathematics, National Institute of Technology Silchar, Silchar, Assam 788010, India.
This study introduces a five-compartment model to account for the impacts of vaccination-induced recovery and nonlinear treatment rates in settings with limited hospital capacity. To reflect real-world scenarios, the model incorporates multiple reinfections in both vaccinated and recovered groups. It reveals a range of dynamics, including a disease-free equilibrium and up to six endemic equilibria.
View Article and Find Full Text PDFNavigating the COVID-19 crisis: a study of healthcare leadership response in India and the USA.
J Health Organ Manag
January 2025
Jindal Global Business School, OP Jindal Global University, Sonipat, India.
Purpose: The COVID-19 pandemic has reignited the debate on effective leadership during a crisis. The study examined healthcare leaders' experiences, challenges and responses amid the COVID-19 crisis in India and the USA.
Design/methodology/approach: Thematic analysis culminated in developing a thematic framework that encapsulates the behavior of operational healthcare leaders in India and the USA to illustrate how they responded to the global pandemic.
Background: Post-COVID cognitive dysfunctions, impacting attention, memory, and learning, might be linked to inflammation-induced blood-brain barrier (BBB) impairment. This study explores post-COVID BBB permeability changes using a non-contrast water-exchange based MRI and their associations with blood Alzheimer's biomarkers.
Method: Sixty-seven participants were classified based on COVID (COV) and cognitive (COG) statuses into three groups: COV+/COG- (n=34), COV+/COG+ (n=23), and COV- (n=10) for comparisons (COV+: Laboratory-verified SARS-CoV-2 infection; COV-: No history of SARS-CoV-2 infection and negative SARS-CoV-2 nucleocapsid antibody test.
Background: Alzheimer's disease (AD), the most common type of dementia, affects at least twenty-four million people globally, yet, the causation, mechanisms of progression, and therapeutic strategies remain elusive. Currently, tRNA-derived RNA fragments (tRFs), a family of recently discovered small non-coding RNAs (sncRNAs), have surfaced as promising biomarkers for many diseases, including AD. Our work revealed that several AD-impacted tRFs in human hippocampus, CSF, and serum.
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Alzheimers Dement
December 2024
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Population Center, Chapel Hill, NC, USA.
Background: Cardiometabolic diseases and mental health disorders, which are high-risk factors for dementia and cognitive decline, are associated with higher mortality and morbidity with age. Interventions before age 60 may lessen the burden of cognitive and physical function in later life. Telehealth offers early intervention and solutions for their complex demands in continuous behavior monitoring and medication refilling.
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