AI Article Synopsis
- The study aims to explore changes in brain activity in patients with high myopia (HM) compared to healthy controls (HCs) using dynamic regional homogeneity (dReHo) analysis.
- Resting-state fMRI scans were conducted on 82 HM patients and 59 HCs, examining the relationship between dReHo values and clinical symptoms in various brain areas.
- Results showed significantly higher dReHo values in certain brain regions (like the left fusiform gyrus and right inferior temporal gyrus) in HM patients, highlighting the potential link between brain network alterations and the pathophysiological mechanisms of HM.
Article Abstract
Aim: Patients with high myopia (HM) reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls (HCs) dynamic regional homogeneity (dReHo) analysis.
Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined correlation analysis.
Results: In the left fusiform gyrus (L-FG), right inferior temporal gyrus (R-ITG), right Rolandic operculum (R-ROL), right postcentral gyrus (R-PoCG), and right precentral gyrus (R-PreCG), dReHo values were significantly greater in patients with HM than in HCs.
Conclusion: Patients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390771 | PMC |
| http://dx.doi.org/10.3389/fnhum.2022.959523 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU.
J Am Anim Hosp Assoc
January 2025
From Neuro Vets Animal Neurology Clinic, Kyoto, Kyoto, Japan (K.H., Y.N., M.N.).
A 5 yr old chihuahua presented to our clinic with a complaint of decreased activity and focal seizures. Based on the findings of MRI and computed tomography, a primary brain tumor originating from the right frontal lobe region was suspected. Surgical resection was performed, and a diagnosis of histiocytic sarcoma was made via histopathological examination and immunohistochemical staining.
View Article and Find Full Text PDFExcitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.
PLoS Comput Biol
January 2025
Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Although the primary function of excitatory-inhibitory (E-I) homeostasis is the maintenance of mean firing rates, the conjugation of multiple homeostatic mechanisms is thought to be pivotal to ensuring edge-of-bifurcation dynamics in cortical circuits. However, computational studies on E-I homeostasis have focused solely on the plasticity of inhibition, neglecting the impact of different modes of E-I homeostasis on cortical dynamics. Therefore, we investigate how the diverse mechanisms of E-I homeostasis employed by cortical networks shape oscillations and edge-of-bifurcation dynamics.
View Article and Find Full Text PDFUniversity students' health-related quality of life and its determinants. Results from a cross-sectional survey during the COVID-19 pandemic.
PLoS One
January 2025
Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Being a university student is a vulnerable period marked by transitions and uncertainties which can impair their physical and mental well-being as well as overall quality of life. The existing literature suggests that certain groups of students might be particularly affected by that. In addition, quality of life might have been further affected by the COVID-19 pandemic.
View Article and Find Full Text PDFEnhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects.
J Physiol
January 2025
Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Short-term disuse leads to rapid declines in muscle mass and strength. These declines are driven by changes at all levels of the neuromuscular system; the brain, spinal cord and skeletal muscle. In addition to neural input from the central and peripheral nervous systems to the muscle, molecular factors originating in the muscle can be transported to the central nervous system.
View Article and Find Full Text PDFEvaluation of single nucleotide polymorphisms in the human norepinephrine transporter (hNET) gene for structural, functional, and pathogenic significance.
Nucleosides Nucleotides Nucleic Acids
January 2025
Department of Molecular Biology and Genetics, Hitit University, Corum, Türkiye.
The norepinephrine transporter (NET) is a key regulator of noradrenergic neurotransmission and homeostasis, regulating the norepinephrine levels in the brain and peripheral tissues. hNET is a major target in neuropsychiatric disorders such as major depressive disorder, autonomic dysfunction, and attention deficit hyperactivity disorder (ADHD). The human norepinephrine transporter gene (, ) contains 504 missense single nucleotide polymorphisms (SNPs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!