All-optical ultrasound (OpUS), where ultrasound is both generated and received using light, has emerged as a modality well-suited to highly miniaturised applications. In this work we present a proof-of-concept OpUS transducer built onto a single optical fibre with a highly miniaturised lateral dimension (<0.8 mm). A key innovation was to use a dual-clad optical fibre (DCF) to provide multimode light for ultrasound generation and single mode light for ultrasound reception. The transducer comprised a proximal section of DCF spliced to a short section of single mode fibre (SMF). Multimode light was outcoupled at the splice joint and guided within a square capillary to provide excitation for ultrasound generation. Whilst single mode light was guided to the distal tip of the SMF to a plano-concave microresonator for ultrasound reception. The device was capable of generating ultrasound with pressures >0.4 MPa and a corresponding bandwidth >27 MHz. Concurrent ultrasound generation and reception from the transducer enabled imaging via motorised pull-back allowing image acquisition times of 4 s for an aperture of 20 mm. Image resolution was as low as ~50 µm and 190 µm in the axial and lateral extents, respectively, without the need for image reconstruction. Porcine aorta was imaged demonstrating detailed ultrasound images. The unprecedented level of miniaturisation along with the high image quality produced by this device represents a radical new paradigm for minimally invasive imaging.
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http://dx.doi.org/10.1364/BOE.459486 | DOI Listing |
Nanoscale
January 2025
Nanomaterials for BioImaging Group (nanoBIG), Departamento de Física de Materiales, Universidad Autónoma de Madrid (UAM), Madrid 28049, Spain.
All-optical theranostic systems are sought after in nanomedicine, since they combine in a single platform therapeutic and diagnostic capabilities. Commonly in these systems the therapeutic and diagnostic/imaging functions are accomplished with plasmonic photothermal agents and luminescent nanoparticles (NPs), respectively. For maximized performance and minimized side effects, these two modalities should be independently activated, , in a decoupled way, using distinct near infrared (NIR) wavelengths: a radiation window wherein photon-tissue interaction is reduced.
View Article and Find Full Text PDFAll-optical ultrasonic probes exhibit notable benefits in ultrasonic detection and imaging. Typically, two separate optical fibers are used for excitation and detection, yet limited research has explored the integration of both functionalities within a single fiber. In this Letter, to our knowledge, a new method for fabricating an all-fiber self-transceiving ultrasonic probe is proposed with a lateral dimension of less than 500 µm.
View Article and Find Full Text PDFNat Biomed Eng
September 2024
Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Cont Lens Anterior Eye
June 2024
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