Aptamers are RNAs that can bind proteins directly and modulate protein-protein interactions. Given their therapeutic potential, aptamers would be expected to capture the interest of both scientists and investors. However, concerns regarding safety, efficacy, and delivery have delayed aptamer development and dampened investor support. Herein, we discuss the major hurdles stalling the translational application of aptamers over recent years and focus on approaches to overcome current barriers and attract the scientific community and investors to the aptamer field.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379498 | PMC |
| http://dx.doi.org/10.1016/j.omtn.2022.07.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mindfulness- and acceptance-based programmes for obsessive-compulsive disorder: A systematic review and meta-analysis.
J Anxiety Disord
January 2025
Department of Psychosomatic Medicine and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Mindfulness- and acceptance-based programmes (MABPs) in the treatment of obsessive-compulsive disorder (OCD) are increasingly gaining research interest, yet a comprehensive systematic review and meta-analysis is missing. To fill this gap, we analysed 46 trials involving 2221 patients. Two independent reviewers screened records, extracted data, assessed risk of bias, and rated overall quality of evidence.
View Article and Find Full Text PDFMechanisms of change in an online acceptance and commitment therapy intervention for insomnia.
Sci Rep
January 2025
Department of Psychology, University of Jyväskylä, P.O. Box 35, Jyväskylä, 40014, Finland.
Insomnia, i.e., difficulty falling asleep or staying asleep, is a common condition that is connected to many psychological and physical problems.
View Article and Find Full Text PDFEnhancing social functioning using multi-user, immersive virtual reality.
Sci Rep
January 2025
Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Rates of loneliness and other forms of social disconnection have been increasing worldwide. Prior studies have suggested that brief behavioral interventions can teach skills that may improve social functioning and connection but, currently, access to such interventions is limited. One previously untested approach for addressing this gap is to teach these skills using immersive, multi-user virtual reality (VR).
View Article and Find Full Text PDFKnowledge, attitude and perception of epilepsy patients toward epilepsy surgery at Jordan University hospital.
Epilepsy Behav
January 2025
Neurology Section/Internal Medicine Department , Jordan University Hospital, Amman 11942, Jordan.
Introduction: Epilepsy is a condition associated with stigma and considerable morbidity, placing a significant burden on patients and their families. It is fundamental to be mindful of the fact that a substantial number of patients remain unaware of the effective surgical procedures that have shown great success in many cases, drawing upon the global underutilization of epilepsy surgery (ES). In this study, we explore the knowledge and attitudes of epilepsy patients towards ES at Jordan University Hospital (JUH).
View Article and Find Full Text PDFSexual Violence and Shame: A Meta-Analysis.
Trauma Violence Abuse
January 2025
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Although sexual violence (SV) has been hypothesized to increase shame, the relationship between SV and shame has not been quantified. Addressing this gap is essential for developing targeted interventions for survivors, as shame is a transdiagnostic risk factor for numerous forms of psychopathology and a barrier to service-seeking. This meta-analysis first examines whether individuals exposed to SV demonstrate higher shame than individuals who reported no SV exposure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!