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Renally Excretable Molybdenum Disulfide Nanoparticles as Contrast Agents for Dual-Energy Mammography and Computed Tomography.
Bioconjug Chem
December 2024
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Article Synopsis
- Contrast-enhanced dual-energy mammography (DEM) can detect tumors better in dense breast tissue than standard mammography, but traditional iodine-based contrast agents have significant limitations, including use restrictions and high doses.* -
- The study introduces ultrasmall molybdenum disulfide nanoparticles (MoS NPs) that are biocompatible and produce higher image contrast in DEM compared to conventional contrast agents like iopamidol.* -
- MoS NPs also show rapid elimination from the body, reducing concerns about long-term toxicity, which suggests they could effectively serve as dual-modality contrast agents for both DEM and CT imaging.*
Water-Soluble Fluorescent Sensors for Quantification of Trace Cisplatin in Body Fluids from Clinical Cancer Patients.
J Am Chem Soc
December 2024
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, Xi'an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi Province 710127, China.
Accurate quantification of cisplatin (cDDP) in body fluids (blood, urine, and ascites) is crucial in monitoring therapeutic processes, assessing drug metabolism, and optimizing treatment schedules for cancer patients. Nonetheless, due to the inherent fluorescence and complexity of the body fluid matrix, along with the low cDDP concentrations in these fluids during treatment, using fluorescent sensors for fluid detection remains a subject of ongoing research. Herein, a series of water-soluble cDDP-activatable fluorescent sensors was rationally constructed by introducing thioether groups to the xanthene skeleton based on the chalcogenophilicity of platinum.
View Article and Find Full Text PDFHigh-throughput and high-sensitive direct detection for pathogenic bacteria of urinary tract infections mediated by block-based design of flexible non-metallic composite SERS substrate.
Biosens Bioelectron
February 2025
Translational Research Laboratory for Urology, Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, PR China. Electronic address:
It remains a huge challenge to realize a high-throughput direct detection for pathogenic bacteria with high-sensitivity in practice. Here, we develop a typical two-dimensional (2D) composite semiconductor of BP@MoS with special synergistic chemical enhancement-mediated surface-enhanced Raman scattering (SERS) activity. The relative proportion of MoS and BP was rationally adjusted in the hydrothermal reaction to screen a composite sample with high charge transfer efficiency.
View Article and Find Full Text PDFUrinary Stone Composition Analysis of 1465 Patients: The First Series from Azerbaijan.
Arch Iran Med
November 2024
Department of Laboratory, State Security Service Military Hospital, Baku, Azerbaijan.
Article Synopsis
- - The study focuses on urinary stone disease in Azerbaijan, analyzing the composition of stones from 1,465 patients using FTIR spectroscopy over nearly a decade.
- - Findings indicate that calcium oxalate stones are the most common type at 56.2%, with uric acid stones following at 33.7%, and show variations based on age and gender.
- - The research suggests a need for customized diagnostic and treatment strategies due to the high prevalence of urinary stones, especially mixed types, highlighting the complexity of this health issue.
Copper Sulfide Nanorod-Embedded Urinary Catheter with Hydrophobicity and Photothermal Sterilization.
Int J Mol Sci
October 2024
International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
The high prevalence of catheter-associated urinary tract infections (CAUTIs) is causing significant concern in healthcare systems. Antibacterial urinary catheters have been developed to prevent CAUTIs in clinical application. In this work, a copper sulfide nanorod (CuS NR)-embedded urinary catheter (CuS/UC) was designed as an antibacterial urinary catheter with photothermal sterilization.
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