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Chemical Profiles and Antiobesity Effect of a Mixture of and Extract in High Fat Diet Fed Mice. | LitMetric

AI Article Synopsis

  • The study investigated the antiobesity potential of ALM16, a mixture of AM and LE extracts, in mice fed a high-fat diet (HFD) over 5 weeks.
  • Findings showed that ALM16 significantly reduced weight gain and body fat increases caused by the HFD, along with improvements in lipid profiles and liver health markers.
  • ALM16 was more effective than using AM or LE alone, indicating that the combination has synergistic effects for combating obesity.

Article Abstract

The present study aimed to evaluate the antiobesity potential and synergistic effects of ALM16, a mixture of (AM) and (LE) extracts, in HFD-induced obese mice. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD + AM, HFD + LE or HFD + ALM16 (50, 100, and 200 mg/kg) daily for 5 weeks. Compared to the ND group, HFD-fed mice showed significant increases in body weight, food efficiency ratio, weights of white adipose tissues, adipocytes size, liver weight, and hepatic steatosis grade. However, ALM16 significantly reduced those increases induced by HFD. Moreover, as compared to the HFD group, the ALM16 group significantly ameliorated serum levels of lipid profiles (TG, TC, HDL, and LDL), adipokines (leptin and adiponectin), and liver damage markers (AST and ALT levels). Notably, ALM16 was more effective than AM or LE alone and had a similar or more potent effect than extracts, as a positive control, at the same dose. These results demonstrate that ALM16 synergistically exerts anti-obesity effects based on complementary interactions between each component. Also, metabolic profiling between each extract and the ALM16 was confirmed by UPLC-QTOF/MS, and the difference was confirmed by relative quantification.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391103PMC
http://dx.doi.org/10.1155/2022/9642427DOI Listing

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