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http://dx.doi.org/10.3389/fimmu.2022.993967 | DOI Listing |
Arthroscopy
January 2025
Bone & Joint Sports Medicine Institute, Department of Orthopaedic Surgery, Naval Medical Center Portsmouth, Portsmouth, VA, USA; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD. Electronic address:
Losartan and other modulators of the Renin-Angiotensin System (RAS) have been used for their anti-fibrotic effects by non-surgeons for decades where suppression of maladaptive scar deposition is helpful, such as heart failure and chronic kidney disease. Only recently have orthopaedic surgeons begun to explore whether these medications might reduce or prevent post-operative joint stiffness. The relationship between orthopaedic surgeons and fibrosis is a more complicated.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Cell Communication in Disease Pathology, School of Human Sciences, London Metropolitan University, London N7 8DB, UK.
The use of animal models is crucial for advancing translational research by identifying effective treatment targets and strategies for clinical application in human disease [...
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.
The extracellular matrix (ECM) serves as a complex network that regulates cellular behavior and maintains tissue architecture [...
View Article and Find Full Text PDFFront Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFFront Immunol
December 2024
Periodontics Department, Dental College of Georgia, Augusta University, Augusta, GA, United States.
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