Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project.

Aims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex.

Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018.

Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy ( < .05). Serum total and low-density lipoprotein cholesterol were greater in males' umbilical cord blood artery compared to females' new-borns (both,  < .05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth ( < .05). Female's placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all,  ⩽ .05), and evidence of statistical significance in telomeres length, which were 17% longer ( = .076).

Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males' foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.