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| http://dx.doi.org/10.1111/jdv.18536 | DOI Listing |
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Expression of PRAME in high-grade serous carcinoma is associated with higher residual disease volume and Occludin expression.
Pathol Res Pract
December 2024
Department of Pathology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Background: Patients with high-grade serous carcinoma (HGSC) are commonly diagnosed at late disease stages and after primary tumors have disseminated in the peritoneum. The overexpression of tight junction proteins has been associated with poor prognosis in this setting, potentially reflecting the tumor´s adaptive changes in the disease cascade.
Methods: By performing immunohistochemistry in a large single-center cohort of a total of 705 HGSC, we test the hypothesis that the protein expression of PReferentially expressed Antigen of MElanoma (PRAME) contains prognostic, predictive or clinically translatable information.
The Influence of Melanoma Extracellular Vesicles on Benign Melanocytes: A Role for PRAME in Modulation of the Tumor Microenvironment.
J Invest Dermatol
November 2024
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Cancer Biology Research Program, Stephenson Cancer Center, Oklahoma City, Oklahoma, USA. Electronic address:
Melanoma is an aggressive skin cancer with a high tendency for metastasis and resistance to conventional therapies. This study explores the role of preferentially expressed antigen in melanoma (PRAME), a cancer-testis antigen, in melanoma progression, focusing on its function in melanoma-derived extracellular vesicles (EVs) and its impact on benign melanocytes. We show that PRAME is highly expressed in melanoma cell lines, tissues, and patient plasma and is present in EVs.
View Article and Find Full Text PDFThe Utility of PRAME and Ki-67 as Prognostic Markers for Cutaneous Melanoma.
Am J Dermatopathol
January 2025
School of Medicine, São Paulo State University, Botucatu, SP, Brazil.
Cutaneous melanoma can lead to metastasis, and it is associated with high mortality. Currently, there are no widely accepted immunohistochemistry markers for melanoma prognosis in routine staging. Preferentially expressed antigen in melanoma (PRAME) is a possible biomarker for prognosis in several noncutaneous neoplasms.
View Article and Find Full Text PDFA comprehensive review of PRAME and BAP1 in melanoma: Genomic instability and immunotherapy targets.
Cell Signal
December 2024
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address:
In a thorough review of the literature, the complex roles of PRAME (preferentially expressed Antigen of Melanoma) and BAP1 (BRCA1-associated protein 1) have been investigated in uveal melanoma (UM) and cutaneous melanoma. High PRAME expression in UM is associated with poor outcomes and correlated with extraocular extension and chromosome 8q alterations. BAP1 mutations in the UM indicate genomic instability and a poor prognosis.
View Article and Find Full Text PDFDigital quantification of PRAME for distinguishing melanoma from nevi compared to manual assessment.
Pathol Res Pract
October 2024
Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark; Department of Pathology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, Aarhus N 8200, Denmark.
Article Synopsis
- This study looked for a new way to help doctors tell the difference between dangerous and harmless skin lesions using a method that digitally measures a substance called PRAME.
- They tested this method on tissue samples and compared it with a traditional manual approach to see how well they could identify melanomas.
- The new digital method was found to be just as accurate as the old method and has benefits like being easier to use and more consistent, but researchers want to test it more with larger groups.
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