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Exosome-based strategies for diagnosis and therapy of glioma cancer. | LitMetric

AI Article Synopsis

  • * Exosomes play a key role in tumor development by facilitating communication in the tumor microenvironment and contributing to processes like tumor growth, metastasis, and resistance to treatment.
  • * The review explores the properties of tumor-derived exosomes, their potential as diagnostic markers, and their therapeutic applications in targeting glioblastoma, emphasizing the need to understand their molecular mechanisms and signaling pathways.

Article Abstract

Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communication are created via exosomes in the tumor microenvironment through the transport of various biomolecules. They are primarily involved in tumor growth, differentiation, metastasis, and chemotherapy or radiation resistance. Recently several studies have highlighted the critical role of tumor-derived exosomes against immune cells. According to the structural and functional properties, exosomes could be essential instruments to gain a better molecular mechanism for tumor understanding. Additionally, they are qualified as diagnostic/prognostic markers and therapeutic tools for specific targeting of invasive tumor cells such as glioblastomas. Due to the strong dependency of exosome features on the original cells and their developmental status, it is essential to review their critical modulating molecules, clinical relevance to glioma, and associated signaling pathways. This review is a non-clinical study, as the possible role of exosomes and exosomal microRNAs in glioma cancer are reported. In addition, their content to overcome cancer resistance and their potential as diagnostic biomarkers are analyzed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394011PMC
http://dx.doi.org/10.1186/s12935-022-02642-7DOI Listing

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