AI Article Synopsis
- - Toxin-antitoxin systems help bacteria fight off phages by shutting down the infected cells, but their exact mechanisms and functions aren't fully understood.
- - Researchers LeRoux et al. have discovered that the DarTG system uses a DNA-targeting activity to hinder the replication of phages.
- - However, phages can bypass this defense through specific inhibitors and by developing a tolerance to the bacterial response.
Article Abstract
Toxin-antitoxin systems can defend bacteria against phages by shutting down infected cells, but the links between their molecular mechanisms and biological functions have remained underexplored. LeRoux et al. now show how the DNA-targeting ADP-ribosylation activity of DarTG impairs phage replication but is overcome by dedicated viral inhibitors and evolved tolerance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tim.2022.08.009 | DOI Listing |
Publication Analysis
Top Keywords
antiviral death
4
death punch
4
punch adp-ribosylating
4
adp-ribosylating bacterial
4
bacterial toxins
4
toxins toxin-antitoxin
4
toxin-antitoxin systems
4
systems defend
4
defend bacteria
4
bacteria phages
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!