AI Article Synopsis
- Tissue adhesives play a crucial role in preventing wound leaks, severe bleeding, and improving drug delivery, but many options lack both high adhesion strength and biocompatibility.
- Recent research has focused on polysaccharide-based tissue adhesives, discussing their mechanisms, applications, and ongoing advancements in the field.
- Future studies should prioritize understanding biomaterials and tissue properties, optimizing fabrication processes, and developing responsive adhesives for better clinical utilization.
Article Abstract
Tissue adhesives have been widely used for preventing wound leaks, sever bleeding, as well as for enhancing drug delivery and biosensing. However, only a few among suggested platforms cover the circumstances required for high-adhesion strength and biocompatibility, without toxicity. Antibacterial properties, controllable degradation, encapsulation capacity, detectability by image-guided procedures and affordable price are also centered to on-demand tissue adhesives. Herein we overview the history of tissue adhesives, different types of polysaccharide-based tissue adhesives, their mechanism of gluing, and different applications of polysaccharide-based tissue adhesives. We also highlight the latest progresses in engineering of tissue adhesives followed by existing challenges in fabrication processes. We argue that future studies have to place focus on a holistic understanding of biomaterials and tissue surface properties, proper fabrication procedures, and development of magnetic and conductive responsive adhesives in order to bridge the huge gap between the present studies for clinical implementation.
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| http://dx.doi.org/10.1016/j.carbpol.2022.119787 | DOI Listing |
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