AI Article Synopsis
- circRNAs are crucial in various biological processes in mammals, but their role in lower vertebrates is less understood.
- A new circular RNA, circRara, was identified and studied for its effects on antiviral and antibacterial responses, as well as cell proliferation in miiuy croaker.
- The study found that circRara expression increases when stimulated, promoting inflammation and antiviral gene production, providing insight into circRNA's role in fish immunity.
Article Abstract
With the in-depth study of circRNA, more and more biological studies have shown that circRNAs play an important role in mammals, such as cell proliferation, apoptosis, invasion, development and disease state. However, the regulatory mechanism of circRNA in lower vertebrates remains unclear. Here, we found a new circular RNA and named it circRara. We carried out the experimental study on its antiviral and antibacterial response, cell proliferation and activity. The results showed that circRara had a positive regulatory effect on the antiviral and antibacterial response, cell proliferation and activity in miiuy croaker. First, we found that the expression of circRara could be up-regulated under the stimulation of LPS and poly (I: C), but not the expression of linear Rara. In addition, the increase of circRara can increase the production of inflammatory factors and antiviral genes, which was confirmed by double luciferase reporter gene experiment and qPCR. These results will help to further understand the immunomodulatory mechanism of circRNA in teleost fish.
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| http://dx.doi.org/10.1016/j.fsi.2022.08.026 | DOI Listing |
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