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Interdependence of Sebaceous Lipids and the Microbiome in Atopic Dermatitis.
J Invest Dermatol
November 2022
Department of Dermatology, University of California San Diego, San Diego, California, USA. Electronic address:
Intermittent Fasting before Laparotomy: Effects on Glucose Control and Histopathologic Findings in Diabetic Rats.
Nutrients
December 2021
Anesthesia Department, São Paulo State University (UNESP)-Botucatu, Botucatu 18618683, Brazil.
(1) Background: Intermittent fasting is a nutrition practice in which individuals fast for several hours in a day, mainly with feeding time during the daylight hours. They seek to improve metabolic performance and cellular resistance to stress. In this study, we tested the fasting protocol to investigate the glycemic effect in a laparotomy perioperative period in diabetic rats and histopathologic findings.
View Article and Find Full Text PDFA Phase 1 Randomized, Placebo-Controlled Trial With a Topical Inhibitor of Stearoyl-Coenzyme A Desaturase 1 Under Occluded and Nonoccluded Conditions.
Clin Pharmacol Drug Dev
April 2019
CMAX, a division of IDT Australia Limited, Adelaide, South Australia, Australia.
Stearoyl-coenzyme A desaturase 1 (SCD-1) in sebaceous glands is a key enzyme in the synthesis of monounsaturated fatty acids essential for acne development. GSK1940029 gel, a novel SCD-1 inhibitor, is being developed as a potential treatment for acne. To assess the irritation potential, pharmacokinetics (PK), and safety of topical GSK1940029 to the skin of healthy adults, two interdependent studies were conducted in parallel.
View Article and Find Full Text PDFDifferentiation of the sebaceous gland.
Dermatoendocrinol
March 2009
Center for Molecular Medicine Cologne (CMMC); University of Cologne; Institute of Pathology; Cologne, Germany.
The sebaceous gland is renewed throughout adult life and homeostasis of this particular organ is controlled by a precise interplay of hormones, cytokines, signalling molecules and mediators of the lipid metabolism. Although the true function of sebaceous glands has yet to be fully determined, recent evidence demonstrates that normal homeostasis of the sebaceous gland and functional lipid metabolism of sebocytes is crucial for maintenance of the skin barrier. In addition, analysis of mutant mouse models revealed a close interdependency of the sebaceous gland with hair follicles because abnormal morphogenesis of sebaceous glands often results in degeneration of hair follicle structures.
View Article and Find Full Text PDFHuman meibomian glands: the ultrastructure of acinar cells as viewed by thin section and freeze-fracture transmission electron microscopies.
Invest Ophthalmol Vis Sci
June 1992
Department of Cytomorphology, University of Cagliari, Italy.
Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably according to their stage of holocrine differentiation. This study shows close interdependence between fat droplets and Golgi apparatus or endoplasmic reticulum.
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