Environmental changes during the Holocene impacted the development of all civilizations, and it is important to understand the power of this influence through, for instance, the reconstruction of these changes. However, when the climate and environmental conditions of the deep past are analyzed, researchers need to rely on various types of proxy data that are only approximations of the required information. In addition, this type of information is often absent or has several gaps (hiatuses). In the present study, we analyzed a 4.4-m deep core excavated from the fen formed within the landslide body on the northern side of Mt. Śnieżnica in the Wyspowy Beskidy Mountains, the Outer Western Carpathians, southern Poland. In total, we analyzed 405 samples in terms of 29 geochemical components (e.g., nitrogen (N), carbon (C), sulfur (S), and the total organic carbon (TOC)) and physical properties, namely particle-size distribution, loss on ignition (LOI), and microcharcoal content. Additionally, to establish geochronology, we dated 27 samples of different biological materials using the Accelerator Mass Spectrometry radiocarbon method. A detailed examination of plant macrodetritus and wood anatomy supported our interpretation based on the geochemical data. The Mt. Śnieżnica landslide probably formed ca. 14,000 cal BP in the first phase of the Allerød Interstadial. For almost 9000 years, there were no appropriate terrain conditions for the long-term accumulation of organo-mineral materials. At ca. 4400 cal BP, peat accumulation commenced. The beginning of peat accumulation correlates with the global 4.2 Bond event of cold climate conditions. After another ca. 2000 years, the core sediments were dominated by limnetic mud, suggesting aquatic conditions in the landslide depression. This sudden shift in the characteristics of sedimentation is loosely linked to the boundary between the Subboreal and Subatlantic phases (ca. 2500 cal BP). The apparent dichotomy of the depositional record agrees with the reconstructed climatic conditions during the second part of the Holocene. Up to 3000 cal BP, the regional climate was warm and humid, which allowed fast biomass production and hillslope stabilization by trees. Forest fires occurred only at the beginning and end of this period (4400-3000 cal BP). After 3000 cal BP, the regional climate became cool and dry. In this period, we found evidence of intensified erosion, but it was unrelated to forest fire activity.
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http://dx.doi.org/10.1016/j.scitotenv.2022.158066 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330006 Nanchang, Jiangxi, China.
Background: It has been reported the therapeutic effects of mesenchymal stem cells (MSCs) on hearing loss. This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on age-related hearing loss (ARHL) and its underlying mechanisms.
Methods: Reverse transcription-quantitative PCR and western blotting were used to evaluate gene expression.
Reprod Toxicol
January 2025
Normandie Univ, UNICAEN, OeReCa, 14000 Caen, France. Electronic address:
This study investigated the effects of bisphenol A (BPA) and the involvement of nuclear estrogen receptors (ESR) on testicular energy metabolism and spermatogenesis in zebrafish. Testes were incubated with DMSO, 10 pM or 10μM BPA for 6 or 72h, with some samples pre-incubated with the ESRα/β antagonist ICI 182,780. Gene and protein expressions were analyzed using real-time PCR and Western blot, respectively.
View Article and Find Full Text PDFBiosensors (Basel)
January 2025
School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
The sensitive detection of inflammatory biomarkers in gingival crevicular fluid (GCF) is highly desirable for the evaluation of periodontal disease. Luminol-based electrochemiluminescence (ECL) immunosensors offer a promising approach for the fast and convenient detection of biomarkers. However, luminol's low ECL efficiency under neutral conditions remains a challenge.
View Article and Find Full Text PDFWe describe and characterize a new species from the Singing honeyeater () in Western Australia, both morphologically and molecularly. Microscopic analysis of a fecal sample identified 25 ellipsoidal oocysts, measuring 21-25 × 18-20 μm (mean 23.4 × 18.
View Article and Find Full Text PDFInt J Pharm
January 2025
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515 China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515 China; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangzhou 510515 China. Electronic address:
Atherosclerosis, a major cause of cardiovascular diseases, involves complex pathophysiological processes. The co-delivery of multiple bioactive components derived from phytomedicine to atherosclerotic plaque is challenging, especially for those with varied solubilities. This study introduces a novel metal-phenolic network-based core-shell recombinant high-density lipoprotein nanocarrier (SSPH-MPN@rHDL) for co-delivering multiple bioactive components from Salvia miltiorrhiza and Carthamus tinctorius, including salvianic acid A (SAA), salvianolic acid B (SAB), protocatechuic aldehyde (PCA), hydroxysafflor yellow A (HSYA), and tanshinone IIA (TS-IIA).
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