Repurposing the repurposed: thalidomide analogs as immune stimulants to overcome T cell exhaustion.

Cell Chem Biol

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

Published: August 2022

In this issue of Cell Chemical Biology, Geng and colleagues employ a novel mouse model of humanized cereblon (Crbn) to provide insights into the immunomodulatory effects of lenalidomide and provide rationale for potential therapeutic combinations including anti-PD1 immunotherapy.

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http://dx.doi.org/10.1016/j.chembiol.2022.07.004DOI Listing

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