Topical Mosquito Repellent Formulations for Enhanced Repellency Time and Reduced Toxicity.

Curr Drug Deliv

Instituto de Ciências Ambientais Químicas e Farmacêuticas, Universidade Federal de São Paulo, Unifesp, Diadema, SP, Brazil.

Published: June 2023

Mosquito-borne diseases such as dengue, malaria, yellow fever, chikungunya and Zika virus affect millions of people worldwide each year. Vector control and personal protection are very important to minimize the spread of diseases, and the use of repellent is an economic practice to prevent them. The application of repellent, which acts on the skin to form a vapor layer with a repellent odor to mosquitos, is recommended as an economic prevention and practice. The natural botanical product Citronella is an effective mosquito repellent due to the high concentrations of active chemical constituents present, notably terpenic alcohols. However, citronella tends to evaporate quickly from the skin surface, resulting in a rapid loss of activity. Strategies to increase repellency time, while at the same time minimizing toxicity, are major focuses of research and development in natural repellent products. Here we highlight the role of extended-release systems (ERS) of citronella oil in this approach.

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http://dx.doi.org/10.2174/1567201819666220818162455DOI Listing

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