AI Article Synopsis
- The aqueous extract and essential oil of oleo-gum resin showed a concentration-dependent reduction in the viability of A549 cancer cells, with the lowest effective doses being 10 g/ml for the extract and 2.5 g/ml for the essential oil.
- Treatment with these substances increased reactive oxygen species (ROS) levels and indicated changes in apoptosis markers, notably with essential oil raising caspase-3 levels while downregulating caspase-9.
- The essential oil appears to induce apoptotic cell death in A549 cells through oxidative stress and mitochondrial membrane potential (MMP) depletion, without relying on mitochondrial cytochrome c release.
Article Abstract
Results: Aqueous extract and essential oil reduced the viability of A549 cancer cells in a concentration-dependent manner. The lowest inhibitory concentrations (IC) for both samples of oleo-gum resin were 10 and 2.5 g/ml for 24 hours in A549 cell line, respectively. After treatment with extract and essential oil of oleo-gum resin, ROS increased significantly compared to the control group. Although changes in caspase-3 did not show a significant increase in extract, the caspase-3 was found to be increased after exposure to essential oil and caspase-9 was downregulated after exposure to essential oil. Also, exposure to essential oil of caused a reduction in MMP level.
Conclusion: Based on results, the cytotoxic effect of essential oil of can induce apoptosis toward A549 cell line via induction of oxidative stress, MMP depletion, and caspase-3 activation, which is independent to mitochondrial cytochrome c release and caspase-9 function.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381248 | PMC |
| http://dx.doi.org/10.1155/2022/9725244 | DOI Listing |
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