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Role of Therapeutic Drug Monitoring in the Treatment of Persistent Central Nervous System Infection: A Case Report and Review of the Literature. | LitMetric
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Role of Therapeutic Drug Monitoring in the Treatment of Persistent Central Nervous System Infection: A Case Report and Review of the Literature.

En-Ling Wu Omar Al-Heeti Brian M Hoff Janna L Williams Karen M Krueger Phillip P Santoiemma Nathaniel J Rhodes

Open Forum Infect Dis

Department of Pharmacy Practice, Midwestern University College of Pharmacy, Downers Grove Campus, Downers Grove, Illinois, USA.

Published: August 2022

A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379816PMC
http://dx.doi.org/10.1093/ofid/ofac392DOI Listing

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