AI Article Synopsis
- A 70-year-old man had coronary artery bypass surgery 28 days after recovering from COVID-19, confirmed by a negative PCR test for the virus.
- During the surgery, samples from his saphenous vein and sputum still tested positive for SARS-CoV-2, indicating the presence of the virus.
- The findings reveal that even after recovery, some patients can continue to shed the virus and may have ongoing immune responses against it.
Article Abstract
A 70-year-old man underwent off-pump coronary artery bypass grafting 28 days after his recovery from coronavirus disease 2019 (COVID-19), which was confirmed by a negative polymerase chain reaction (PCR) test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a nasopharyngeal swab. The PCR test result was also negative for nasopharyngeal sampling 5 days prior to the surgery. However, his redundant saphenous vein and sputum through the endotracheal tube that was taken on the operative day showed the presence of SARS-CoV-2 by PCR. Immunohistochemical analysis of Spike and Nucleoprotein of the saphenous vein showed small clusters of each antigen-positive speckle. Ultrastructural imaging of the saphenous vein showed virus-like particles. The cell-based assay suggested that the patient's serum contained a higher concentration of type-I interferons than that of healthy control sera. These observations suggest that internal viral shedding and, to some extent, innate immune responses continue after COVID-19 recovery.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379344 | PMC |
| http://dx.doi.org/10.3389/fmed.2022.959196 | DOI Listing |
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