Correlation of Clinical Course with Computed Tomography Findings and Biochemical Parameters at the Time of Admission in COVID-19 Patients.

Objective: The primary objective of our study was to evaluate the predictive performance of serum inflammatory markers and the semiquantitative computed tomography severity scoring system on diagnosing the Covid 2019 disease and its course.

Methods: Our study is a single-center retrospective cohort study. The data of 213 adults who were confirmed to have coronavirus disease 2019 by polymerase chain reaction tests in the period between April 2020 and August 2020 were evaluated. One hundred eighty four of these patients whose C-reactive protein, d-dimer, and ferritin levels, lymphocyte counts, and thoracic computed tomography images were obtained at the time of admission were included in the study. The semi-quantitative computed tomography severity score was calculated for all patients.

Results: The median age of the 184 patients included in the study was 51.5 (19-91) years. The incidence of intensive care need and mortality was 10.3% (n=19) and 5.4% (n=10), respectively. The intensive care need and mortality rate was significantly correlated with higher thoracic computed tomography involvement scores at admission. There was a statistically significant and positive correlation between the computed tomography scores and the C-reactive protein, d-dimer, and ferritin levels. Older age (>65 years-old) and thoracic computed tomography scores of 11 and higher were independent factors correlated with need for intensive care.

Conclusion: Serum inflammatory markers and semi-quantitative computed tomography severity scoring system were predictive in diagnosing the Covid 2019 disease and its course.