High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377245 | PMC |
| http://dx.doi.org/10.1080/2162402X.2022.2111915 | DOI Listing |
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