Objectives: Burning mouth syndrome is an intraoral chronic pain condition characterized by a moderate to severe sensation of burning from the oral mucosa. No clinical signs are found and there is no efficient treatment.
Method And Materials: This pilot study included 10 women that were resistant to other previous treatments or noncompliant to systemic medications. Patients were asked to apply tretinoin gel 0.05% on their tongues twice daily for 14 days. Treatment effectiveness was assessed by completing a pre-study psychologic questionnaire and recording a daily wellbeing and pain log.
Results: Significant pain-score decrease in 50% of the patients (delta numerical rating score -3.15 ± 3.02, P value = .005) was recorded. This finding was in concordance with the verbal statements including major quality-of-life improvement (P value = .05), without any treatment positive or negative predictive factors.
Conclusions: Topical tretinoin exhibits potential efficacy in patients with treatment resistant burning mouth syndrome and may also be used as a primary treatment modality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3290/j.qi.b3315031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Considering SOD and miRNA analysis as potential prognostic markers in white lesion malignant transformation: A report of two cases.
Medicine (Baltimore)
December 2024
Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic.
Article Synopsis
- Predictive biomarkers can help identify oral leukoplakia with a higher risk of becoming cancerous, which is crucial for timely intervention.
- Two patients presented with oral burning sensations and white lesions, leading to a diagnosis confirmed through tissue analysis.
- The study found specific changes in microRNA expressions and antioxidant enzyme activities in patients, indicating a link between these molecular changes and the risk of malignant transformation.
Introduction: The Mandibular Function Impairment Questionnaire (MFIQ) was developed for clinical assessment of functional impairment in patients with temporomandibular disorder (TMD). It allows patients to rank difficulty performing 17 jaw-related functions as low, moderate or severe. Our study was designed to determine whether the MFIQ is also helpful in differentiating TMD from other causes of orofacial pain in a clinical setting.
View Article and Find Full Text PDFBurning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.
Oral Dis
December 2024
Department of Preventive Medicine, Public Health and History of Science, Complutense University of Madrid, Madrid, Spain.
Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS).
Subjects And Methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).
Results: The structure of the associative pathways with the BMS was revealed.
Pathophysiology of oral lesions subsequent to SARS-CoV-2 vaccination: A systematic review.
J Oral Maxillofac Pathol
October 2024
Kasturba Medical College, Manipal, Karnataka, India.
Amidst worldwide reports of adverse oral lesions subsequent to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, the current systematic review planned to determine the prevalence of adverse oral events in adult individuals (≥18 years) after SARS-CoV-2 vaccination, emphasizing upon the type and dose of vaccine, time of onset, and underlying pathophysiology. The registered protocol (PROSPERO CRD42023421307), conforming with PRISMA guidelines, included an all-inclusive literature search through online databases, consisting of Scopus, PubMed/MEDLINE, Web of Science, Lilacs, Livivo, and PROSPERO, completed on 2 May 2023, followed by assessment of risk of bias by Joana Briggs Institute Evaluation Checklist. Due to the paucity of literature, case reports and case series were included.
View Article and Find Full Text PDFA pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.
Clin Oral Investig
December 2024
Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Objectives: To explore the potential role of oral bacteria in the pathogenesis of burning mouth syndrome (BMS).
Materials And Methods: Fifteen patients with BMS and 15 healthy controls were enrolled in this study. The relative abundance and diversity of salivary bacterial strains were analyzed using metagenomic DNA sequencing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!